{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:20:10Z","timestamp":1793215210839,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T00:00:00Z","timestamp":1332288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no established management algorithm for portal vein thrombosis (<jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>) in cirrhotic patients. The aim of our study was to prospectively evaluate anticoagulation and transjugular intrahepatic portosystemic shunt (<jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>) to treat <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cirrhotics with non\u2010malignant <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content> were included. <jats:styled-content style=\"fixed-case\">Low weight molecular heparin<\/jats:styled-content> anticoagulation was considered in all; <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> was indicated if thrombosis progressed or anticoagulation was contraindicated. Patients who were not anticoagulated nor received <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six patients (of whom 21 controls) were included. <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content> was occlusive in 11\/35, with extension to the superior mesenteric or splenic vein in 13\/35. In the study group 33 patients were anticoagulated, with a recanalization rate of 36% (12\/33) compared with 1\/21 among controls. A time interval between appearance of thrombosis and anticoagulation &lt;\u00a06\u00a0months predicted chance of repermeation. Thrombus progression occurred in 15\/21 non anticoagulated patients and in 5\/33 anticoagulated patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> was placed in six patients. There were five variceal bleedings and two intestinal venous ischaemia episodes in the control group, compared with one variceal bleeding episode in the study group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cirrhotics with <jats:styled-content style=\"fixed-case\">PVT<\/jats:styled-content>, a treatment algorithm using anticoagulation and <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> achieves a good chance of complete repermeation, reduces portal hypertensive complications, and decreases the rate of thrombosis progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2012.02785.x","type":"journal-article","created":{"date-parts":[[2012,3,23]],"date-time":"2012-03-23T02:00:55Z","timestamp":1332468055000},"page":"919-927","source":"Crossref","is-referenced-by-count":293,"title":["Prospective evaluation of anticoagulation and transjugular intrahepatic portosistemic shunt for the management of portal vein thrombosis in cirrhosis"],"prefix":"10.1111","volume":"32","author":[{"given":"Marco","family":"Senzolo","sequence":"first","affiliation":[{"name":"Multivisceral Transplant Unit, Gastroenterology, Department of Surgical and Gastroenterological Sciences University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"M. Sartori","sequence":"additional","affiliation":[{"name":"Second Chair Internal Medicine, Department of Cardiologic, Thoracic and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rossetto","sequence":"additional","affiliation":[{"name":"Second Chair Internal Medicine, Department of Cardiologic, Thoracic and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Burra","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Gastroenterology, Department of Surgical and Gastroenterological Sciences University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Department of Surgical and Gastroenterological Sciences University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Boccagni","sequence":"additional","affiliation":[{"name":"Liver Transplant Center, Department of Surgical and Gastroenterological Sciences University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Gasparini","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology, Department of Surgery &amp; Transplantation University Hospital of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Miotto","sequence":"additional","affiliation":[{"name":"Radiology Section, Department Medical Diagnostic Sciences and Special Therapies University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[{"name":"Second Chair Internal Medicine, Department of Cardiologic, Thoracic and Vascular Sciences University of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Tsochatzis","sequence":"additional","affiliation":[{"name":"The Royal Free Sheila Sherlock Liver Centre Dept. of Surgery UCL, Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"A. Burroughs","sequence":"additional","affiliation":[{"name":"The Royal Free Sheila Sherlock Liver Centre Dept. of Surgery UCL, Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160515"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04182.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.03.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310213"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200507000-00009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21941"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80259-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02820.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22503"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.16597"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23259"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181b3ab44"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042796"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21209"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33210"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.003"},{"key":"e_1_2_6_19_1","first-page":"259","article-title":"[Venous thromboembolism and liver cirrhosis]","volume":"100","author":"Garcia\u2010Fuster MJ","year":"2008","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199809)59:1<22::AID-AJH5>3.0.CO;2-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90004-0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194904000-00013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01822.x"},{"key":"e_1_2_6_24_1","first-page":"S113","volume":"48","author":"Primignani M","year":"2008","journal-title":"Am J Transplant"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.027"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1478-3231.2012.02785.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1478-3231.2012.02785.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T03:20:41Z","timestamp":1698636041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1478-3231.2012.02785.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,21]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1478-3231.2012.02785.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1478-3231.2012.02785.x","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,21]]}}}