{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:56:32Z","timestamp":1791309392441,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatocellular adenomas (<jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>) are rare benign tumours occurring mainly in women using oral contraceptives. With the appearance of a generation of new oral contraceptives, the number of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> cases was anticipated to decrease, but in fact this was not observed in our practice. The influence of obesity was therefore suspected as a new co\u2010factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to analyze the impact of overweight\/obesity in our cohort of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> patients classified according to their subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> noticeably increased faster in the 2001\u20132011 period compared to the 1990\u20132000 period. This phenomenon concurred with an increasing number of patients overweight or obese. Females still represented the great majority of overweight\/obese patients presenting <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>, however, overweight\/obese male patients constituted a new entity in the inflammatory <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> and \u03b2\u2010catenin activated\u2010 inflammatory <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose that overweight\/obesity may soon represent a major risk of malignant transformation of <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>, possibly via the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2012.02786.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T03:01:35Z","timestamp":1332212495000},"page":"1217-1221","source":"Crossref","is-referenced-by-count":119,"title":["Hepatocellular adenoma subtypes: the impact of overweight and obesity"],"prefix":"10.1111","volume":"32","author":[{"given":"Paulette","family":"Bioulac\u2010Sage","sequence":"first","affiliation":[{"name":"Service d'anatomie pathologique H\u00f4pital Pellegrin CHU Bordeaux Bordeaux France"},{"name":"Inserm U1053 Universit\u00e9 Bordeaux 2 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Taouji","sequence":"additional","affiliation":[{"name":"Inserm U1053 Universit\u00e9 Bordeaux 2 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Possenti","sequence":"additional","affiliation":[{"name":"Service d'anatomie pathologique H\u00f4pital Pellegrin CHU Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Balabaud","sequence":"additional","affiliation":[{"name":"Inserm U1053 Universit\u00e9 Bordeaux 2 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21068"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21743"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22995"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02862.x"},{"key":"e_1_2_6_7_1","unstructured":"HAS.Surpoids et ob\u00e9sit\u00e9 de l'adulte: prise en charge m\u00e9dicale de premier recours M\u00e9thode \u201cRecommandations pour la pratique clinique\u201c. 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