{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:48:03Z","timestamp":1792619283037,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,4,22]],"date-time":"2012-04-22T00:00:00Z","timestamp":1335052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Differentiating steatosis from NASH is key in deciding treatment and follow\u2010up schedules. We hypothesized that sonographic grading of steatosis will correlate with metabolic and pathologic changes of NASH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three non\u2010consecutive patients had a semi\u2010quantitative evaluation of hepatic steatosis through ultrasonographic Fatty Liver Indicator (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>) just prior to liver biopsy. All biopsies demonstrated <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content> is a new scoring system ranging 2\u20138 based on the intensity of liver\/kidney contrast, posterior attenuation of ultrasound beam, vessel blurring, difficult visualization of gallbladder wall, difficult visualization of the diaphragm and areas of focal sparing. <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> is diagnosed by the minimum score \u22652. Ultrasonographic findings were correlated with metabolic and histological data. Inter\u2010observer <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content> score agreement, evaluated by three different operators in 31 consecutive patients with steatosis, showed \u201calmost perfect\/substantial\u201d agreement (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content> showed a positive correlation with <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>, insulin, uric acid, ferritin, <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> and bilirubin and was associated with steatosis extent assessed histologically and histological features of <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>, except for fibrosis. <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content> was an independent predictor of <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> (OR 2.236; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and a <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u00a0&lt;\u00a04 had a high negative predictive value (94%) in ruling out the diagnosis of severe <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content> according to <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>leiner's criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data confirm the hypothesis that US\u2010FLI significantly correlates with metabolic derangements and individual pathologic criteria for NASH and may better select patients for liver biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1478-3231.2012.02804.x","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T04:30:57Z","timestamp":1335155457000},"page":"1242-1252","source":"Crossref","is-referenced-by-count":182,"title":["Ultrasonographic fatty liver indicator, a novel score which rules out <scp>NASH<\/scp> and is correlated with metabolic parameters in <scp>NAFLD<\/scp>"],"prefix":"10.1111","volume":"32","author":[{"given":"Stefano","family":"Ballestri","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Lonardo","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics University of Modena and Reggio Emilia Modena 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