{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T19:02:51Z","timestamp":1767034971227},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T00:00:00Z","timestamp":1170028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To evaluate the efficacy and safety of PGE<jats:sub>1<\/jats:sub> analogue, misoprostol, for inducing abortion or labour during mid\u2010trimester in women who have had a prior Caesarean section (one or more).<\/jats:p><jats:p><jats:bold>Study design:\u2002<\/jats:bold> Women who had to undergo termination of pregnancy between 13 and 26 weeks of gestation for various indications and who had at least one previous Caesarean section were studied over a period of two and a half years. The standard regimen for misoprostol in all the cases was 400\u00a0\u00b5g up to 20 weeks of gestation and 200\u00a0\u00b5g for pregnancies longer than 20 weeks, either vaginally or sublingually every six hours (up to maximum 24\u00a0h). A contemporaneous cohort of women undergoing the same procedure for similar indications but without scarred uteri served as control.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Eighty women in the study group underwent termination procedures for unwanted pregnancy, missed abortion, fetal anomaly or fetal death. The median induction\u2013abortion interval was 16.4\u00a0h (10\u201321\u00a0h) and did not differ much from that in women without previous Caesarean delivery (median: 15.6\u00a0h; range 9.6\u201320\u00a0h), <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05. Misoprostol was found to be safe in our cohort of post\u2010Caesarean women and there was no case of scar rupture or dehiscence. No significant differences in rates of incomplete abortions, blood loss or sepsis were detected in the study group compared to the control group.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The use of misoprostol for mid\u2010trimester pregnancy termination is not contraindicated in women with Caesarean scar and is effective and comparable with those in women without scarred uteri.<\/jats:p>","DOI":"10.1111\/j.1479-828x.2006.00673.x","type":"journal-article","created":{"date-parts":[[2007,1,29]],"date-time":"2007-01-29T09:46:57Z","timestamp":1170064017000},"page":"23-25","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Misoprostol for termination of mid\u2010trimester post\u2010Caesarean pregnancy"],"prefix":"10.1111","volume":"47","author":[{"given":"Nabendu","family":"BHATTACHARJEE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra Prasad","family":"GANGULY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyama Prasad","family":"SAHA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80019-6"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00335-X"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02365-8"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200111001-00037"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00409-5"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00121-0"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00347-8"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151996.16422.88"},{"key":"e_1_2_8_10_2","first-page":"111","article-title":"Prostaglandins in late 1st and early 2nd trimester MTP","volume":"51","author":"Bhattacharjee N","year":"2001","journal-title":"J Obstet Gynecol India"},{"key":"e_1_2_8_11_2","first-page":"139","article-title":"Comparison of prostaglandin E1 (misoprostol) with prostaglandin E2 (dinoprostone) for labor induction","volume":"54","author":"Sahu L","year":"2004","journal-title":"J Obstet Gynecol India"},{"key":"e_1_2_8_12_2","first-page":"178","article-title":"Vaginal misoprostol for medical evacuation of missed abortion","volume":"55","author":"Sakhare AP","year":"2005","journal-title":"J Obstet Gynecol India"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(01)00261-X"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01075.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70049-9"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00363-4"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1479-828X.2006.00673.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1479-828X.2006.00673.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:45:24Z","timestamp":1697093124000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1479-828X.2006.00673.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,29]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1479-828X.2006.00673.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1479-828x.2006.00673.x","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,29]]},"assertion":[{"value":"2007-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}