{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:48:48Z","timestamp":1760122128045},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T00:00:00Z","timestamp":1326844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The management of antepartum haemorrhage of unknown origin (<jats:styled-content style=\"fixed-case\">APHUO<\/jats:styled-content>) remote from term remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the rate and risk factors in predicting preterm delivery among women presenting with <jats:styled-content style=\"fixed-case\">APHUO<\/jats:styled-content> before 34\u00a0weeks of gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All singleton pregnancies with the first episode of <jats:styled-content style=\"fixed-case\">APHUO<\/jats:styled-content> before 34\u00a0weeks of gestation who delivered between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 1995 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2004 were reviewed. The predictability of risk factors was assessed by both univariate and multivariate analysis. The cumulative rates of preterm delivery prior to 34\u00a0weeks were compared by using the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier survival analysis and log\u2010rank test between those with and those without risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rates of preterm delivery prior to 34 and 37\u00a0weeks of gestation were 7.3 and 17%, respectively. Uterine contractions, persistent bleeding, two or more episodes of <jats:styled-content style=\"fixed-case\">APHUO<\/jats:styled-content> and a history of spontaneous preterm deliveries were significant risk factors for preterm birth prior to 34\u00a0weeks in a multivariate logistic regression. Women with one risk factor had a hazard ratio of 5.5 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.2\u20139.6) in having preterm delivery prior to 34\u00a0weeks compared with those without risk factors, whereas women with any two risk factors had a hazard ratio of 5.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.1\u201312.9) compared with those with one risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">APHUO<\/jats:styled-content> prior to 34\u00a0weeks of gestation is associated with three to fivefold increased risk of preterm delivery. Identification of several risk factors could further help to predict early preterm delivery and appropriate triage management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1479-828x.2011.01401.x","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T06:38:45Z","timestamp":1326868725000},"page":"167-172","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The risk of preterm delivery prior to 34\u00a0weeks in women presenting with antepartum haemorrhage of unknown origin"],"prefix":"10.1111","volume":"52","author":[{"given":"Sik Wing","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Hung","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Y.K.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000182881.53139.f7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780303.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01856.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052980"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443619867821"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1994.tb02674.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh180"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.1999.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13430"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa002868"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01327.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70240-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01931.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.04104.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602293340904"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00645.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2617"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1479-828X.2011.01401.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1479-828X.2011.01401.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T01:12:08Z","timestamp":1697418728000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1479-828X.2011.01401.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,18]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1111\/j.1479-828X.2011.01401.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1479-828x.2011.01401.x","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,18]]},"assertion":[{"value":"2011-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}