{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:12Z","timestamp":1790488392087,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,15]],"date-time":"2012-02-15T00:00:00Z","timestamp":1329264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The gold standard for diagnosis of proteinuria in pre\u2010eclampsia is traditionally a 24\u2010h urine collection. Current <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian guidelines advocate use of the spot urine protein\u2010to\u2010creatinine ratio (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>); however, there is controversy in the international literature about its accuracy and little recent Australian data exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the accuracy of the spot urine <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">a cohort of A<\/jats:styled-content>ustralian women with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with pre\u2010eclampsia over a 52\u2010month period from a single obstetric unit were included in the study. Spot urine <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, 24\u2010h urine collection, gestation at delivery, severe hypertension in labour and magnesium sulphate requirement were recorded. Primary analysis of predictive values was performed on women who had had both a spot urine <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> and a 24\u2010h collection. Continuous data were assessed using least squares analysis with <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>earson correlation coefficient, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>land\u2013<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ltman plot and receiver operator characteristics curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and seventeen women had pre\u2010eclampsia, and 121 of these underwent both tests. The two tests were highly correlated (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.98, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The urine <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> had a positive predictive value of 94% and a sensitivity of 95% for predicting proteinuria. There were no significant increases in the diagnosis of severe hypertension in labour nor the need for magnesium sulphate infusion in labour in those women in whom the 24\u2010h collection was omitted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The urine <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> is highly accurate in predicting significant proteinuria in women with pre\u2010eclampsia using the recommended cut\u2010off of 30\u00a0mg\/mmol. Our findings support current guidelines suggesting the use of a 24\u2010h urine collection is now rarely required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1479-828x.2011.01409.x","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T02:45:05Z","timestamp":1329360305000},"page":"179-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The accuracy of spot urinary protein\u2010to\u2010creatinine ratio in confirming proteinuria in pre\u2010eclampsia"],"prefix":"10.1111","volume":"52","author":[{"given":"Thomas J.","family":"Cade","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Geelong Hospital Geelong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey A.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Geelong Hospital Geelong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology Royal Women's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Hotchin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Geelong Hospital Geelong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,15]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Maternal Deaths in Australia 2003\u20132005. 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