{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:05:42Z","timestamp":1770505542842,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:00:00Z","timestamp":1330387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A low\u2010lying placenta detected at the mid\u2010pregnancy ultrasound is commonly reported to warn against potential morbidity associated with placenta praevia. There is no information on what distance away from the internal cervical os is safe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We examined whether a low\u2010lying placenta not overlapping the cervical os in the second trimester increases the risk of obstetric complications and whether there is a cut\u2010off point at which that increase occurs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adverse perinatal outcomes were examined prospectively in a cohort of women with a placenta 0\u201330\u00a0mm from the internal cervical os (\u2018low\u2010lying\u2019) at the routine mid\u2010trimester ultrasound and compared to those with a placenta further away. Two composite outcomes of \u2018major\u2019 and \u2018minor\u2019 adverse events were predefined as primary outcome measures, requiring a sample size of 480 women with a low\u2010lying placenta. Chi\u2010square and Fisher's exact tests were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 1662 pregnancies (\u2018low\u2010lying\u2019: <jats:italic>n<\/jats:italic>\u00a0=\u00a0484; \u2018normal\u2019: <jats:italic>n<\/jats:italic>\u00a0=\u00a01178), there was no increase in composite adverse outcomes with a low\u2010lying placenta and no cut\u2010off distance within 30\u00a0mm from the cervical os at which risks increased. Postpartum haemorrhage \u22651000\u00a0<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> was more frequent with a low\u2010lying placenta (7.6% vs 4.7%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with a low\u2010lying placenta, not overlapping the cervical os, in mid\u2010pregnancy are at no higher risk of adverse outcomes than those with a normally located placenta, except postpartum haemorrhage. This suggests that the high\u2010risk label can be removed from pregnancies with a low\u2010lying placenta not overlapping the cervical os in mid\u2010pregnancy, reducing anxiety and resource utilisation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1479-828x.2012.01416.x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T10:15:46Z","timestamp":1330424146000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Precise mid\u2010trimester placenta localisation: Does it predict adverse outcomes?"],"prefix":"10.1111","volume":"52","author":[{"given":"Alice J.","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash Medical Centre Melbourne Victoria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Muller","sequence":"additional","affiliation":[{"name":"Women's and Children's Hospital, 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