{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:08:49Z","timestamp":1787962129320,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T00:00:00Z","timestamp":1338163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) is the most common cause of anovulatory infertility. Lifestyle change alone is considered the first\u2010line treatment for the management of infertile anovulatory <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women who are overweight or obese. First\u2010line medical ovulation induction therapy to improve fertility outcomes is clomiphene citrate, whilst gonadotrophins, laparoscopic ovarian surgery or possibly metformin are second line in clomiphene citrate\u2010resistant <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. There is currently insufficient evidence to recommend aromatase inhibitors over that of clomiphene citrate in infertile anovulatory <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women in general or specifically in therapy naive or clomiphene citrate\u2010resistant <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women. <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> treatment is recommended either as a third\u2010line treatment or in the presence of other infertility factors.<\/jats:p>","DOI":"10.1111\/j.1479-828x.2012.01448.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T03:23:21Z","timestamp":1338261801000},"page":"400-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["The treatment of infertility in polycystic ovary syndrome: a brief update"],"prefix":"10.1111","volume":"52","author":[{"given":"Michael F.","family":"Costello","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology University of New South Wales Sydney NSW Australia"},{"name":"Department of Reproductive Medicine Royal Hospital for Women Sydney NSW Australia"},{"name":"IVF Australia Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L.","family":"Misso","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventative Medicine, Monash University Melbourne NSW Australia"},{"name":"Jean Hailes for Women's Health Research Unit Melbourne NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Diabetes Southern Health Melbourne NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Hart","sequence":"additional","affiliation":[{"name":"School of Women's and Infant's Health, The University of Western Australia Perth WA Australia"},{"name":"Fertility Specialists of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luk","family":"Rombauts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Monash University Melbourne NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Melder","sequence":"additional","affiliation":[{"name":"Centre for Clinical Effectiveness, Southern Health Melbourne NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Norman","sequence":"additional","affiliation":[{"name":"The Robinson Institute University of Adelaide Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J.","family":"Teede","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventative Medicine, Monash University Melbourne NSW Australia"},{"name":"Jean Hailes for Women's Health Research Unit Melbourne NSW Australia"},{"name":"Department of Diabetes Southern Health Melbourne NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.05.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-41"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_7_5_1","unstructured":"PCOS Australian Alliance.Evidence\u2010based guideline for the assessment and management of polycystic ovary syndrome 2011. [Accessed 29 August 2011.] Available from URL:www.managingpcos.org.au\/pcos-evidence-based-guidelines."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10915"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007506.pub2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/GCO.0b013e32833beebf","article-title":"Letrozole for ovulation induction and controlled ovarian hyperstimulation","volume":"22","author":"Pritts EA","year":"2010","journal-title":"Curr Opin Obstet Gynecol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328332d188"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3280c60c9a"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002249.pub4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.09.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90209-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003053.pub4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31816a4ed4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm026"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03369.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0689"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.08.033"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.11.042"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei501"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006105.pub2"},{"key":"e_1_2_7_24_1","first-page":"CD001122","article-title":"Laparoscopic \u2018drilling\u2019 by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome","volume":"3","author":"Farquhar C","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61273-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der401"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01705-2"},{"issue":"1","key":"e_1_2_7_28_1","first-page":"O\u2013231","article-title":"The outcome of 150 babies following the treatment with letrozole or letrozole and gonadotropins","volume":"84","author":"Biljan MM","year":"2005","journal-title":"Fertil Steril"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.03.014"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32551-8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.06.008"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms003"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.03.024"},{"key":"e_1_2_7_34_1","first-page":"956","article-title":"Polycystic ovarian syndrome treated by ovarian electrocautery through the laparoscope","volume":"49","author":"Gjonnaess H","year":"1984","journal-title":"Fertil Steril"},{"key":"e_1_2_7_35_1","first-page":"45","article-title":"The effect of short\u2010interval laparoscopic lysis of adhesions on pregnancy rates following Nd\u2010YAG laser photocoagulation of polycystic ovaries","volume":"80","author":"Gurgan T","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem426"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi036"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr004"}],"container-title":["Australian and New Zealand Journal of Obstetrics and Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1479-828X.2012.01448.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1479-828X.2012.01448.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:16:15Z","timestamp":1697408175000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/j.1479-828X.2012.01448.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,28]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1111\/j.1479-828X.2012.01448.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1479-828x.2012.01448.x","archive":["Portico"],"relation":{},"ISSN":["0004-8666","1479-828X"],"issn-type":[{"value":"0004-8666","type":"print"},{"value":"1479-828X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,28]]},"assertion":[{"value":"2012-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}