{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:25:14Z","timestamp":1770956714282,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust NZ J Obst Gynaeco"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cervidil<jats:sup>\u00ae<\/jats:sup> (dinoprostone) intravaginal pessaries are used for induction of labour and maintain serum prostaglandin levels for up to 24\u00a0h. The Therapeutic Goods Administration approves Cervidil<jats:sup>\u00ae<\/jats:sup> for 12\u2010h use. However, twenty\u2010four\u2010hour use of Cervidil<jats:sup>\u00ae<\/jats:sup> is supported in Europe, New Zealand, America and some Australian hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the safety of Cervidil<jats:sup>\u00ae<\/jats:sup> use for up to 24\u00a0h for induction of labour in nulliparous women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of 269 consecutive women receiving Cervidil<jats:sup>\u00ae<\/jats:sup> at the Royal Brisbane and Women's Hospital (<jats:styled-content style=\"fixed-case\">RBWH<\/jats:styled-content>) between July 2007 and December 2008 was performed. The primary outcome measures were frequency of, and time to, uterine tachysystole with or without fetal heart rate (<jats:styled-content style=\"fixed-case\">FHR<\/jats:styled-content>) changes. Secondary outcome measures included frequency of maternal (intrapartum temperature, postpartum haemorrhage) and neonatal (low Apgars, resuscitation, nursery admission) morbidity. Morbidity outcomes of those who received Cervidil<jats:sup>\u00ae<\/jats:sup> for less than or equal to 12\u00a0h were compared with those who received Cervidil<jats:sup>\u00ae<\/jats:sup> for more than 12\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Uterine tachysystole occurred in 9.3% of patients receiving Cervidil<jats:sup>\u00ae<\/jats:sup>, with a mean time to tachysystole of 10\u00a0h. The majority of cases (68%) occurred within 12\u00a0h of use. There was no increase in maternal or neonatal morbidity for those who received Cervidil<jats:sup>\u00ae<\/jats:sup> for longer than 12\u00a0h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Twenty\u2010four\u2010hour use of Cervidil<jats:sup>\u00ae<\/jats:sup> is likely as safe as 12\u2010h use for induction of labour in nulliparous women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1479-828x.2012.01482.x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T19:40:14Z","timestamp":1348602014000},"page":"582-587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dinoprostone vaginal pessary for induction of labour: Safety of use for up to 24\u00a0h"],"prefix":"10.1111","volume":"52","author":[{"given":"Kellie","family":"Tathem","sequence":"first","affiliation":[{"name":"Royal Brisbane &amp; Women's Hospital \u2010 Women's and Newborn Services Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa J.","family":"Harris","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"O'Rourke","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Kimble","sequence":"additional","affiliation":[{"name":"Royal Brisbane &amp; Women's Hospital \u2010 Women's and Newborn Services Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"LawsPJ HilderL.Australia's mothers and babies 2006. 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