{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T14:56:09Z","timestamp":1772290569676,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Functional gastrointestinal symptoms are frequently found in elderly dementia patients. In such a case, we attempt treatment by the administration of antidepressants or second\u2010generation antipsychotics. However, these medications have a risk of side\u2010effects. In the present study, we carried out oral administration of Rikkunshi\u2010to to elderly dementia patients with appetite loss, and examined its effects on food intake.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Six elderly dementia patients were recruited from inpatients. They showed appetite loss, but no organic abnormalities of the gastrointestinal organs. These patients were given Rikkunshi\u2010to, at 7.5\u2003g per day, t.i.d. for 4\u2003weeks. We examined the food intake, weight, total protein, albumin and potassium in plasma before administration and for 4\u2003weeks after administration. In statistical analyses, the percentage of food consumed for 4\u2003weeks was analyzed by <jats:sc>anova<\/jats:sc>. We also examined the side\u2010effects of Rikkunshi\u2010to.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In patient 3, we stopped investigation after 3\u2003weeks because of the development of cholecystitis. The values of 4\u2003weeks in patient 3 were calculated as the mean values of 4\u2003weeks in the other five patients. <jats:sc>anova<\/jats:sc> and Tukey's multiple comparison showed a marginally significant difference in weight between before Rikkunshi\u2010to was given and 4\u2003weeks after. In change of food intake, there were no significant differences between before Rikkunshi\u2010to was given and 1\u2003day after, 1\u2003day and 2\u2003days after, 2\u2003days and 3\u2003days after, 3\u2003days and 1\u2003week after, and 1\u2003week and 2\u2003weeks after; however, there were significant increases in food intake between other times. With regard to the side\u2010effects, mild lower limb oedema appeared in the two patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In the present study, we showed the effect of Rikkunshi\u2010to in improving appetite loss in elderly dementia patients. The present study suggests that Rikkunshi\u2010to might be useful in improving functional appetite loss in elderly dementia patients, because there are no serious side\u2010effects.<\/jats:p>","DOI":"10.1111\/j.1479-8301.2010.00347.x","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T09:47:16Z","timestamp":1301478436000},"page":"34-39","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Rikkunshi\u2010to on appetite loss found in elderly dementia patients: a preliminary 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