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Besides confirming the major role of classic allelic variants (e.g. apolipoprotein E) in the development of AD, GWAS have thus far implicated over 20 single nucleotide polymorphisms in AD. In this review, we summarize the findings of 16 AD\u2010based GWAS performed to date whose public registries are available at the National Human Genome Research Institute, with an emphasis on understanding whether the polymorphic markers under consideration support functional implications to the pathophysiological role of the major genetic risk factors unraveled by GWAS.<\/jats:p>","DOI":"10.1111\/j.1479-8301.2011.00378.x","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T08:01:12Z","timestamp":1319702472000},"page":"62-73","source":"Crossref","is-referenced-by-count":17,"title":["Lessons from genome\u2010wide association studies findings in Alzheimer's disease"],"prefix":"10.1111","volume":"12","author":[{"given":"Clayton F.","family":"MORAES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulio C.","family":"LINS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Einstein F.","family":"CARMARGOS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janeth O. 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