{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:11:59Z","timestamp":1698732719717},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T00:00:00Z","timestamp":1329436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Rivastigmine is a cholinesterase inhibitor for treatment of mild to moderate Alzheimer's disease (AD) and dementia associated with Parkinson's disease. The new patch formulation was recently made available. We assessed the safety, tolerability, and cognitive outcome of rivastigmine patch in treatment of mild to moderate AD in clinical practice in Thailand.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A multicentre, hospital\u2010based, prospective observational study was conducted in nine hospitals across Thailand. Patients with probable mild to moderate AD who received the rivastigmine patch were enrolled. Data were collected data at baseline, weeks 4\u20138 and after week16.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A total of 116 AD patients were screened, and three were excluded. Of 113 patients, 62.8% were women with a mean age of 73.3\u2003\u00b1\u20039.2\u2003years; 79.7% were newly diagnosed. One\u2010third of all patients had been using antipsychotic or antidepressant medication. Common comorbidities were hypertension and dyslipidemia. The Thai Mental State Examination score significantly increased from 18.6 to 20.3 (weeks 4\u20138) and 20.4 (week 16+) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Scores based on physicians\u2019 (Clinical Global Impression) and caregivers\u2019 (Patients\u2019 Caregiver Global Impression of Change) impressions of improvement suggested minimal improvement. Because of adverse events, seven patients's dosages were reduced 10\u2003cm<jats:sup>2<\/jats:sup> to 5\u2003cm<jats:sup>2<\/jats:sup> or from 5\u2003cm<jats:sup>2<\/jats:sup> to nothing. Itching was the most common adverse symptom.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> During the first 16\u2003weeks after initiation of rivastigmine patch therapy, patients with probable mild to moderate AD had statistically significant improvement in cognitive function, but clinically marginal benefit. Rivastigmine was safe and well tolerated.<\/jats:p>","DOI":"10.1111\/j.1479-8301.2012.00403.x","type":"journal-article","created":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T07:21:22Z","timestamp":1329463282000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Rivastigmine patch for treatment of Alzheimer's disease in clinical practice in Thailand"],"prefix":"10.1111","volume":"13","author":[{"given":"Kongkiat","family":"KULKANTRAKORN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panas","family":"TANYAKITPISAL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somchai","family":"TOWANABUT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charungthai","family":"DEJTHEVAPORN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonsri","family":"RANGSEEKAJEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunsanee","family":"PONGPAKDEE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somsak","family":"LAPTIKULTHAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kritsada","family":"RODPRASERT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwanna","family":"SETTHAWATCHARAWANICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bandit","family":"THINKHAMROP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S026646230200034X","article-title":"Clinical and cost\u2010effectiveness of donepezil, rivastigmine, and galantamine for Alzheimer's disease. A systematic review","volume":"3","author":"Clegg A","year":"2002","journal-title":"Int J Technol Assess Health Care"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100242"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125000471"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1788"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1806"},{"key":"e_1_2_6_7_2","first-page":"58","article-title":"Transdermal rivastigmine patch in outpatient services in Austria: a naturalistic study in 103 patients with Alzheimer dementia","volume":"1","author":"Schmidt R","year":"2009","journal-title":"Neuropsychiatr"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02641.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2165\/11315320-000000000-00000"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007991003688888"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008330161"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.563"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.11.1457"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31818b1c2c"},{"key":"e_1_2_6_15_2","first-page":"188","article-title":"Safety and tolerability of rivastigmine transdermal patch compared with rivastigmine capsules in patients switched from donepezil: data from three clinical trials","volume":"2","author":"Sadowsky CH","year":"2010","journal-title":"Int J Clin Pract"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903439717"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/11531270-000000000-00000"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02713.x"}],"container-title":["Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1479-8301.2012.00403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1479-8301.2012.00403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:05:03Z","timestamp":1698699903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1479-8301.2012.00403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,17]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/j.1479-8301.2012.00403.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1479-8301.2012.00403.x","archive":["Portico"],"relation":{},"ISSN":["1346-3500","1479-8301"],"issn-type":[{"value":"1346-3500","type":"print"},{"value":"1479-8301","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,17]]}}}