{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:35:31Z","timestamp":1761975331212},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychogeriatrics"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To examine whether the diagnosis method of neuronal dysfunction (DIMENSION<\/jats:styled-content>), a new electroencephalogram (EEG<\/jats:styled-content>) analysis method, reflected pathological changes in the early stages of A<\/jats:styled-content>lzheimer's disease (AD<\/jats:styled-content>), we conducted a comparative study of cerebrospinal fluid markers and single\u2010photon emission computed tomography.<\/jats:p><\/jats:sec>Methods<\/jats:title>Subjects cincluded 32 patients in the early stages of AD<\/jats:styled-content> with a Mini\u2010Mental State Examination score \u226524 (14 men, 18 women; mean age, 77.3 \u00b1 9.2 years). Cerebrospinal fluid samples were collected from AD<\/jats:styled-content> patients, and cerebrospinal fluid levels of phosphorylated tau protein (p\u2010tau) 181 and amyloid \u03b2 (A<\/jats:styled-content>\u03b2) 42 were measured with sandwich ELISA<\/jats:styled-content>. EEG<\/jats:styled-content> recordings were performed for 5\u2009min with the subjects awake in a resting state with their eyes closed. Then, the mean value of the EEG<\/jats:styled-content> alpha dipolarity (D<\/jats:styled-content>\u03b1) and the standard deviation of the EEG<\/jats:styled-content> alpha dipolarity (D<\/jats:styled-content>\u03c3) were calculated with DIMENSION<\/jats:styled-content>. Single\u2010photon emission computed tomography analyses were also performed for comparison with DIMENSION<\/jats:styled-content> measures.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with parietal hypoperfusion had significantly increasing p\u2010tau181, decreasing D<\/jats:styled-content>\u03b1, and increasing D<\/jats:styled-content>\u03c3. In addition, there was a negative correlation between D<\/jats:styled-content>\u03b1 and p\u2010tau181, p\u2010tau181\/A<\/jats:styled-content>\u03b242, and a positive correlation between D<\/jats:styled-content>\u03c3 and p\u2010tau181\/A<\/jats:styled-content>\u03b242.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>D<\/jats:styled-content>\u03b1 and D<\/jats:styled-content>\u03c3 were related to cerebral hypoperfusion and p\u2010tau181\/A<\/jats:styled-content>\u03b242. DIMENSION<\/jats:styled-content> was able to detect changes in the early\u2010stage A<\/jats:styled-content>lzheimer's brain, suggesting that it is possibility as a useful examination for early\u2010stage AD<\/jats:styled-content> with a difficult discrimination in clinical conditions. Moreover, EEG<\/jats:styled-content> measurement is a quick and easy diagnostic test and is useful for repeated examinations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1479-8301.2012.00431.x","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T07:49:48Z","timestamp":1371023388000},"page":"63-70","source":"Crossref","is-referenced-by-count":9,"title":["The relationship between the diagnosis method of neuronal dysfunction (DIMENSION<\/scp>) and brain pathology in the early stages of A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"13","author":[{"given":"Minoru","family":"Kouzuki","sequence":"first","affiliation":[{"name":"Department of Biological Regulation School of Health Science Faculty of Medicine Tottori University Yonago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Asaina","sequence":"additional","affiliation":[{"name":"Shinsei Hospital Kurayoshi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyako","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Biological Regulation School of Health Science Faculty of Medicine Tottori University Yonago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimitsu","family":"Musha","sequence":"additional","affiliation":[{"name":"Brain Functions Laboratory, Inc. 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