{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T18:03:54Z","timestamp":1748109834487},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T00:00:00Z","timestamp":1105488000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal osteodystrophy is an important complication of chronic kidney disease characterized by abnormal bone turnover with varied bone histologic changes. Etiology is multifactorial including abnormalities of serum calcium, phosphorus, and 1,25(OH)<jats:sub>2<\/jats:sub>\u2010vitamin D deficiency; secondary hyperparathyroidism; age; cause of kidney disease; diet; renal replacement therapy; and drug therapy. In addition, there is evidence that there may be ethnic differences. Our study is a description of a case series of hormonal and biochemical abnormalities of bone disease in end\u2010stage renal disease patients in South India. A total of 115 patients were studied; 86% were on hemodialysis and 14% were on peritoneal dialysis (age, 47.31\u2003\u00b1\u200314.66 years). Sixty\u2010eight% were men. Diabetes was the cause of end\u2010stage renal disease in 29.5%. Intact parathyroid hormone (PTH) level was 124.6\u2003\u00b1\u2003174.9\u2003pg\/mL and less than twice normal in 69.5% of patients. Hypocalcemia was present in 16.5% and hyperphosphatemia in 35.7% of patients. Empirical vitamin D was prescribed in 40% of patients. Age, sex, diabetic status, and vitamin D use were similar in patients with high PTH (130\u2003pg\/mL) and low PTH levels (&lt;\u2003130\u2003pg\/mL). Bone histologic studies were not performed owing to economic limitation. But the biochemical and hormonal results are suggestive of a mild form of osteodystrophy in Indian patients. Etiology remains uncertain but differences in dietary intake, tropical climate, vitamin D activation, vitamin D receptor polymorphism, parathyroid gland sensitivity, and PTH target organ sensitivity may account for the difference in pattern in bone disease.<\/jats:p>","DOI":"10.1111\/j.1492-7535.2005.01119.x","type":"journal-article","created":{"date-parts":[[2005,1,12]],"date-time":"2005-01-12T13:28:59Z","timestamp":1105536539000},"page":"63-67","source":"Crossref","is-referenced-by-count":6,"title":["Parathyroid hormone and biochemical profile in chronic kidney disease patients in South India"],"prefix":"10.1111","volume":"9","author":[{"given":"Suresh","family":"Sankarasubbaiyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgi","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Soundararajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Chandrasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Padma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg166"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07407.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00426.x"},{"issue":"6","key":"e_1_2_5_5_2","first-page":"594","article-title":"Spectrum of renal diseases in Indian adults","volume":"46","author":"Dash SC","year":"2000","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330307"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.64"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.226"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.380"},{"issue":"2","key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1681\/ASN.V112330","article-title":"Race is a major determinant of secondary hyperparathyroidism in uremic patients","volume":"11","author":"Gupta A","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1177\/089686089901902S65","article-title":"Renal osteodystrophy in predialysis patients: Ethnic difference","volume":"19","author":"Shin SK","year":"1999","journal-title":"Perit Dial Int"},{"key":"e_1_2_5_12_2","volume-title":"Country health profile\u2013India [Internet]","year":"2004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.10.2494"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.11.2779"},{"issue":"5","key":"e_1_2_5_15_2","first-page":"202","article-title":"Calcitropic hormonal status in north Indian patients with end\u2010stage renal disease","volume":"12","author":"Singh AK","year":"1999","journal-title":"Natl Med J India"},{"issue":"1","key":"e_1_2_5_16_2","first-page":"1","article-title":"Renal osteodystrophy in patients with end stage renal disease","volume":"3","author":"Rao M","year":"1993","journal-title":"Ind J Nephrol"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1492-7535.2005.01119.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1492-7535.2005.01119.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T06:10:08Z","timestamp":1697350208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1492-7535.2005.01119.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1111\/j.1492-7535.2005.01119.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1492-7535.2005.01119.x","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}