{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:01:05Z","timestamp":1790737265516,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":4237,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1111\/j.1523-1755.2004.05409.x","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T14:15:02Z","timestamp":1081865702000},"page":"1551-1555","source":"Crossref","is-referenced-by-count":19,"title":["Gene therapy in renal diseases"],"prefix":"10.1016","volume":"65","author":[{"given":"Enyu","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Takabatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Mizui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0010","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1056\/NEJMra022296","article-title":"Alport's syndrome, Goodpasture's syndrome, and type IV collagen","volume":"348","author":"Hudson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0015","first-page":"21","article-title":"Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system\u2014First steps towards gene therapy of Alport syndrome","volume":"3","author":"Heikkila","year":"1996","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0020","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/sj.gt.3301342","article-title":"Adenovirus-mediated transfer of type IV collagen alpha5 chain cDNA into swine kidney in vivo: Deposition of the protein into the glomerular basement membrane","volume":"8","author":"Heikkila","year":"2001","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ki.1996.297","article-title":"Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis","volume":"50","author":"Akagi","year":"1996","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0030","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1046\/j.1523-1755.2003.00865.x","article-title":"Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis","volume":"63","author":"Carl","year":"2003","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0035","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1172\/JCI429","article-title":"Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo","volume":"101","author":"Maeshima","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0040","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/sj.gt.3301243","article-title":"Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo","volume":"7","author":"Tomita","year":"2000","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0045","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/sj.gt.3301926","article-title":"Suppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney","volume":"10","author":"Choi","year":"2003","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0050","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1073\/pnas.96.23.13375","article-title":"Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis","volume":"96","author":"Munger","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0055","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/j.1523-1755.2000.00360.x","article-title":"Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction","volume":"58","author":"Isaka","year":"2000","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/sj.gt.3301681","article-title":"Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats","volume":"9","author":"Nakamura","year":"2002","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0065","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/01.ASN.0000067632.04658.B8","article-title":"Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO Model","volume":"14","author":"Lan","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0070","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1046\/j.1523-1755.2002.t01-1-00650.x","article-title":"Ligand-regulatable erythropoietin production by plasmid injection and in vivo electroporation","volume":"62","author":"Terada","year":"2002","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0075","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1046\/j.1523-1755.2001.00717.x","article-title":"Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases","volume":"59","author":"Matsumoto","year":"2001","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0080","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1046\/j.1523-1755.2001.0590041304.x","article-title":"Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy","volume":"59","author":"Mizuno","year":"2001","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0085","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1523-1755.2002.kid579.x","article-title":"Hepatocyte growth factor gene therapy retards the progression of chronic obstructive nephropathy","volume":"62","author":"Gao","year":"2002","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0090","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/01.ASN.0000031827.16102.C1","article-title":"Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis","volume":"13","author":"Yang","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0095","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/01.ASN.0000069223.98703.8E","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria","volume":"14","author":"Shimizu","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1523-1755.2003.00781.x","article-title":"Gene transfer of truncated IkappaB alpha prevents tubulointerstitial injury","volume":"63","author":"Takase","year":"2003","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0105","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000045420","article-title":"New paradigm of gene therapy: Skeletal-muscle-targeting gene therapy for kidney disease","volume":"83","author":"Imai","year":"1999","journal-title":"Nephron"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0110","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nm0496-418","article-title":"Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney","volume":"2","author":"Isaka","year":"1996","journal-title":"Nat Med"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1523-1755.1999.00275.x","article-title":"Gene therapy by transforming growth factor-beta receptor-IgG Fc chimera suppressed extracellular matrix accumulation in experimental glomerulonephritis","volume":"55","author":"Isaka","year":"1999","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0120","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1046\/j.1523-1755.2001.00728.x","article-title":"Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis","volume":"59","author":"Nakamura","year":"2001","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0125","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1089\/10430349950016717","article-title":"Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells","volume":"10","author":"Yokoo","year":"1999","journal-title":"Hum Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1182\/blood.V98.1.57","article-title":"Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome","volume":"98","author":"Yokoo","year":"2001","journal-title":"Blood"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0135","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1172\/JCI118681","article-title":"In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia","volume":"97","author":"Noiri","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0140","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ki.1996.338","article-title":"Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat","volume":"50","author":"Haller","year":"1996","journal-title":"Kidney Int"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0145","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/01.ASN.0000059339.14780.E4","article-title":"Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury","volume":"14","author":"Furuichi","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0150","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1681\/ASN.V114747","article-title":"CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft","volume":"11","author":"Tomasoni","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00007890-199801270-00002","article-title":"Fas ligand gene transfer to renal allografts in rats: effects on allograft survival","volume":"65","author":"Swenson","year":"1998","journal-title":"Transplantation"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0160","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1097\/00007890-200004270-00027","article-title":"Fas ligand gene transfer prolongs rat renal allograft survival and down-regulates anti-apoptotic Bag-1 in parallel with enhanced Th2-type cytokine expression","volume":"69","author":"Ke","year":"2000","journal-title":"Transplantation"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0165","first-page":"24506","article-title":"Adenovirus-mediated gene transfer of IL-4 prolongs rat renal allograft survival and inhibits the p21(ras)-activation pathway","volume":"32","author":"Kato","year":"2002","journal-title":"Transplant Proc"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0170","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.gt.3300881","article-title":"Allograft transduction of IL-10 prolongs survival following orthotopic liver transplantation","volume":"6","author":"Shinozaki","year":"1999","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0175","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/00007890-200103150-00020","article-title":"Prolongation of allograft survival with viral IL-10 transfection in a highly histoincompatible model of rat heart allograft rejection","volume":"71","author":"Zuo","year":"2001","journal-title":"Transplantion"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0180","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/332161a0","article-title":"Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes","volume":"332","author":"Madsen","year":"1988","journal-title":"Nature"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0185","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nrc1122","article-title":"Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy","volume":"3","author":"Kohn","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0190","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1681\/ASN.V1261280","article-title":"Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats","volume":"12","author":"Azuma","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0195","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1172\/JCI11808","article-title":"Hepatocyte growth factor ameliorates acute graft-versus-host disease and promotes hematopoietic function","volume":"107","author":"Kuroiwa","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0200","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/sj.gt.3301743","article-title":"Application of SFHR to gene therapy of monogenic disorders","volume":"9","author":"Goncz","year":"2002","journal-title":"Gene Ther"},{"key":"10.1111\/j.1523-1755.2004.05409.x_bb0205","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nbt1202-1197b","article-title":"Expectations and reality in gene repair","volume":"20","author":"Yoon","year":"2003","journal-title":"Nat Biotech"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815498825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815498825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T15:36:05Z","timestamp":1623771365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815498825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0085253815498825"],"URL":"https:\/\/doi.org\/10.1111\/j.1523-1755.2004.05409.x","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}