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Glycine\u2010conjugated bile acids are precipitated by acid; thus, any mechanism that would increase the duodenal acid load may remove the inhibitory bile and allow unrestrained growth of<jats:italic>H. pylori<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>These data and speculations offer one possible explanation for why duodenal ulcer occurs in only some people\u2014those with high acid secretion\u2014and suggest that the combination of high duodenal acid load and<jats:italic>H. pylori<\/jats:italic>infection is sufficient to result in duodenal ulcer disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1523-5378.1997.06b08.x","type":"journal-article","created":{"date-parts":[[2007,6,27]],"date-time":"2007-06-27T14:42:26Z","timestamp":1182955346000},"page":"44-49","source":"Crossref","is-referenced-by-count":14,"title":["Perturbations in Gastric Physiology in<i>Helicobacter pylori<\/i>Duodenal Ulcer: Are They All Epiphenomena?"],"prefix":"10.1111","volume":"2","author":[{"given":"David Y.","family":"Graham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Pina","family":"Dore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,27]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"In: Sleisenger M Fordtran J eds. 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