{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:03:32Z","timestamp":1773421412587,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T00:00:00Z","timestamp":1116201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background.\u2002<\/jats:bold> Follicular gastritis is thought to be caused by <jats:italic>Helicobacter pylori<\/jats:italic> infection. However, the pathophysiology of it remains unclear.<\/jats:p><jats:p><jats:bold>Materials and methods.\u2002<\/jats:bold> We assessed gastric acidity in 15 patients with follicular gastritis, aged 20\u201337\u00a0years, using a 24\u2010hour intragastric pH\u2010metry, as well as by histologic and serologic evaluations; and compared it with that in other age\u2010matched groups: 18 cases of <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive antrum\u2010predominant gastritis, 12 of pangastritis, and 24 <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative normals. In eight cases with follicular gastritis, it was re\u2010assessed 6 months after the eradication therapy for <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> During nighttime, the percentage of time with intragastric pH above 3.0 in follicular gastritis was significantly higher than that in normals (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.0001), and in antrum\u2010predominant gastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.001), but was comparable with that in pangastritis. In the daytime period, this parameter in follicular gastritis was significantly higher than that in normal (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.001), in antrum\u2010predominant gastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.001), and in pangastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.05). Marked mononuclear cell and neutrophil infiltration but no apparent glandular atrophy were observed in both the antrum and corpus. Serum pepsinogen I\/II ratio was significantly lower in follicular gastritis than that in normals (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.0001) and in antrum\u2010predominant gastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.001), whereas serum gastrin was significantly higher than that in normals (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.0001), in antrum\u2010predominant gastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.01) and in pangastritis (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.05). After eradication for <jats:italic>H.\u00a0pylori<\/jats:italic>, all of the parameters in follicular gastritis were altered to the same ranges as those in normals.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> In follicular gastritis, gastric acidity is significantly reduced, but can be normalized by eradication of <jats:italic>H.\u00a0pylori<\/jats:italic>. It can thus be speculated that inflammatory cytokines or <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infection\u2013induced prostaglandins might strongly inhibit gastric acid secretion in follicular gastritis.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2005.00318.x","type":"journal-article","created":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T15:31:11Z","timestamp":1116257471000},"page":"256-265","source":"Crossref","is-referenced-by-count":23,"title":["Gastric Acidity in Patients with Follicular Gastritis is Significantly Reduced, but Can be Normalized After Eradication for <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"10","author":[{"given":"Tomohiko","family":"Shimatani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hyogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiya","family":"Yokozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinari","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tazuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Horikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobue","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"22","article-title":"Follow up studies on chronic gastritis\u2010clinical studies of miliary patterns that appear like goose flesh, gastroscopically","volume":"5","author":"Ohtaki H","year":"1991","journal-title":"J Jpn Physicians Assoc"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199010000-00005"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(88)96205-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199007000-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01298868"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199604000-00017"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026624206987"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023016000096"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-001-0575-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(02)80078-0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90374-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70075-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_15_2","first-page":"249","article-title":"H. pylori is a major risk factor in nocturnal intragastric pH elevation and the decrease of gastric acid secretion in old age","volume":"59","author":"Shimatani T","year":"1998","journal-title":"Digestion"},{"key":"e_1_2_5_16_2","first-page":"261","article-title":"Findings in nodular gastritis. 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