{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:48:06Z","timestamp":1768736886723,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T00:00:00Z","timestamp":1126828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background.\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> infection is one of the most common chronic bacterial infections worldwide. Despite the existence of a breath test for the diagnosis of <jats:italic>H. pylori<\/jats:italic> infection, no study has described the composition of volatile compounds, especially the levels of nitrate, in the exhaled air of patients with <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Materials and Methods.\u2002<\/jats:bold> The volatile compounds in the exhaled air of 14 patients suffering from <jats:italic>H. pylori<\/jats:italic> gastritis and 11 controls were analyzed using proton transfer reaction \u2013mass spectrometry. Gastric biopsy was used to establish diagnosis of current <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> Comparing mass spectra between groups, Mass 28 (hydrogen cyanide, HCN) and Mass 64 (hydrogen nitrate, H<jats:sub>2<\/jats:sub>NO<jats:sub>3<\/jats:sub>) were found to be significantly elevated in patients with <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> The main result of the present study is that in <jats:italic>H. pylori<\/jats:italic>\u2010infected patients, levels of exhaled hydrogen nitrate and hydrogen cyanide are found to be significantly elevated. However, further studies are necessary to find out whether the differences in the detected mass spectrum are specific enough to differentiate patients with <jats:italic>H. pylori<\/jats:italic> gastritis from healthy controls.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2005.00345.x","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T15:53:52Z","timestamp":1126886032000},"page":"385-390","source":"Crossref","is-referenced-by-count":28,"title":["<i>H. pylori<\/i> Infection Increases Levels of Exhaled Nitrate"],"prefix":"10.1111","volume":"10","author":[{"given":"Matthias","family":"Lechner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alban","family":"Karlseder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Niederseer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Lirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Neher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Rieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Tilg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,9,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-004-0250-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2.4.599"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.6.2115"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07552-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2003.09309.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.9.861"},{"key":"e_1_2_6_8_2","first-page":"181","article-title":"Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening","volume":"113","author":"Rieder J","year":"2001","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.58"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","unstructured":"WLindingerAHJordan A.On\u2010line monitoring of volatile organic compounds at pptv levels by means of proton\u2010transfer\u2010reaction mass spectrometry (PTR\u2010MS) medical applications food control and environmental research.Int. 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