{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T23:38:13Z","timestamp":1792971493210,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T00:00:00Z","timestamp":1126828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background.\u2002<\/jats:bold> A small proportion of patients suffering from chronic active gastritis are diagnosed with gastric <jats:italic>Helicobacter<\/jats:italic> species other than <jats:italic>Helicobacter pylori<\/jats:italic>. Circumstantial evidence has suggested that these bacteria, also referred to as \u201c<jats:italic>Helicobacter heilmannii<\/jats:italic>\u201d\u2010like organisms (HHLO), may be transmitted through animals. The isolation of a <jats:italic>Helicobacter\u00a0bizzozeronii<\/jats:italic> strain from a human patient confirmed this hypothesis. It was the aim of the present study to assess the presence of animal <jats:italic>Helicobacter<\/jats:italic> species and <jats:italic>H.\u00a0pylori<\/jats:italic> in humans infected with HHLO, as diagnosed by histology.<\/jats:p><jats:p><jats:bold>Methods.\u2002<\/jats:bold> Paraffin\u2010embedded gastric biopsy specimens of 108 HHLO\u2010infected patients (42 women and 66 men) from three clinical centers were screened for the presence of animal gastric <jats:italic>Helicobacter<\/jats:italic> species by polymerase chain reaction (PCR), using assays targeting the 16S rDNA region of the three known canine and feline helicobacters (<jats:italic>H.\u00a0bizzozeronii<\/jats:italic>, <jats:italic>H.\u00a0salomonis<\/jats:italic> and <jats:italic>H.\u00a0felis<\/jats:italic>), \u201c<jats:italic>Candidatus<\/jats:italic> H. suis\u201d, and \u201c<jats:italic>Candidatus<\/jats:italic> H. bovis\u201d. In addition, the presence of <jats:italic>H.\u00a0pylori<\/jats:italic> was evaluated by multiplex PCR analysis.<\/jats:p><jats:p><jats:bold>Results.\u2002<\/jats:bold> In 63.4% of the stomachs (64\/101) classification of the <jats:italic>Helicobacter<\/jats:italic> infection into the above mentioned groups was achieved. Non\u2010<jats:italic>pylori Helicobacter<\/jats:italic> species commonly colonizing the stomachs of cats and dogs were found in 48.5% (49\/101) of the patients. Fourteen (13.9%) samples tested positive for \u201c<jats:italic>Candidatus<\/jats:italic> H. suis\u201d, and \u201c<jats:italic>Candidatus<\/jats:italic> H. bovis\u201d was demonstrated in 1 (0.9%) patient. The presence of <jats:italic>H.\u00a0pylori<\/jats:italic> was established in 13 patients (12.9%). Eleven stomachs (10.9%) were infected with at least two different <jats:italic>Helicobacter<\/jats:italic> species<jats:italic>.<\/jats:italic><\/jats:p><jats:p><jats:bold>Conclusions.\u2002<\/jats:bold> This study identifies animal <jats:italic>Helicobacter<\/jats:italic> species in the stomach of a large series of HHLO\u2010infected patients, which may have clinical implications in a subset of patients with gastric disease.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2005.00347.x","type":"journal-article","created":{"date-parts":[[2005,9,16]],"date-time":"2005-09-16T15:53:52Z","timestamp":1126886032000},"page":"398-406","source":"Crossref","is-referenced-by-count":74,"title":["Detection of Non\u2010<i>pylori Helicobacter<\/i> Species in \u201c<i>Helicobacter heilmannii<\/i>\u201d\u2010Infected Humans"],"prefix":"10.1111","volume":"10","author":[{"given":"Dominic","family":"De Groote","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen\u2010Jan","family":"Van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Van den Bulck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vandamme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Debongnie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Burette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Haesebrouck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Ducatelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,9,16]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Contribution \u00e0 l\u2019Etude des Bact\u00e9ries de la Bouche \u00e0 l\u2019\u00e9tat Normal et dans la Fi\u00e8vre Typhoide","author":"Rappin.","year":"1881"},{"key":"e_1_2_6_3_2","first-page":"433","article-title":"\u00dcber das Spirillum des S\u00e4ugetiermagens und sein Verhalten zu den Belegzellen","volume":"19","author":"Salomon H","year":"1898","journal-title":"Zbl Bakt Parasitenkd Infektionskr Hyg Abt"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91404-A"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.2.137"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025059"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199803000-00011"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61696-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91364-5"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02064190"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.2.379"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.585"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-49-4-1769"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-4-975"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-46-1-160"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.1197-1199.2001"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01586196"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0706.010622"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-49-4-1707"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1271-1276.1998"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/JCM.38.1.13-17.2000","article-title":"The efficacy of laboratory diagnosis of Helicobacter pylori infections in gastric biopsy specimens is related to bacterial density and vacA, cagA, and iceA genotypes","volume":"38","author":"Van Doorn LJ","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2999980"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.4.1510-1516.2001"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1128\/AEM.64.10.3998-4006.1998","article-title":"Isolation and identification of Helicobacter species from canine and feline gastric mucosa","volume":"64","author":"Jalava K","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_27_2","first-page":"201","article-title":"Helicobacter\u2010like organisms in the stomach of pigs with and without gastric ulceration","volume":"7","author":"Melnichouk SI","year":"1999","journal-title":"Swine Health Prod"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087765"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171422"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409094888"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91758-2"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.5.1366-1370.1998"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200303000-00021"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90392-1"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1996.tb00018.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00145.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00949.x"},{"key":"e_1_2_6_38_2","first-page":"1453","article-title":"Ultrastructure of a spiraled microorganism in the gastric mucosa of dogs","volume":"31","author":"Lockard VG","year":"1970","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1045-1048.1999"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1523-5378.2005.00347.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1523-5378.2005.00347.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:26:28Z","timestamp":1697084788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1523-5378.2005.00347.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,16]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["10.1111\/j.1523-5378.2005.00347.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1523-5378.2005.00347.x","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,16]]}}}