{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:18:00Z","timestamp":1767986280027,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The clinical features and clinical course of <jats:italic>Helicobacter pylori<\/jats:italic>\u2010negative gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma are unclear and a treatment strategy has not yet been established.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To clarify the clinical differences between <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive and <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative gastric MALT lymphoma, we compared these two types of gastric MALT lymphoma.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Fifty\u2010seven patients with localized gastric MALT lymphoma were studied. <jats:italic>H.\u00a0pylori<\/jats:italic> infection was present in 41 and absent in 16. Treatment consisted of antibiotic therapy and\/or 30 Gy radiation therapy. Response assessment was performed every 3\u20136\u00a0months by esophagogastroduodenoscopy including gathering biopsy samples, endoscopic ultrasonography, clinical examination, and various imaging procedures. The median follow\u2010up period was 37\u00a0months.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were no significant differences between <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive and <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative gastric MALT lymphoma patients in terms of sex, age, stage, gross phenotype, affected area of the stomach, or the presence of monoclonality. Complete regression was achieved with antibiotic therapy against <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative gastric MALT lymphoma in one of nine patients (11.1%), compared to 28 of 38 patients (73.7%) with <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive gastric MALT lymphoma (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a0.001). Radiation therapy showed high effectiveness for the local control of <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative or antibiotic\u2010resistant gastric MALT lymphoma (92.9%), although distant recurrence was recognized in three of 14 patients (21.4%). Two of 16 patients (12.5%) with <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative gastric MALT lymphoma died because of the transformation of the disease into diffuse large B\u2010cell lymphoma. There was a significant difference in both the overall and cause\u2010specific survival rate between the two groups (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.038).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Radiation therapy is the effective treatment for <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative or antibiotic\u2010resistant localized gastric MALT lymphoma. However, careful systemic follow\u2010up for distant involvement should be required. Transformation into diffuse large B\u2010cell lymphoma is thought to be the important cause of death in patients with gastric MALT lymphoma.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2006.00382.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T14:32:27Z","timestamp":1141828347000},"page":"86-95","source":"Crossref","is-referenced-by-count":54,"title":["Comparison of Localized Gastric Mucosa\u2010Associated Lymphoid Tissue (MALT) Lymphoma with and without <i>Helicobacter pylori<\/i> 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