{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:36:32Z","timestamp":1760121392901},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T00:00:00Z","timestamp":1141776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To evaluate whether or not genetic polymorphism of <jats:italic>IL\u20101B<\/jats:italic>, <jats:italic>IL\u20101RN<\/jats:italic>, and <jats:italic>TNF\u2010\u0391<\/jats:italic> is an important factor in the different expression of gastroduodenal diseases after <jats:italic>Helicobacter\u00a0pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This study consisted of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first\u2010degree gastric cancer relative (GCR). <jats:italic>IL\u20101\u0392<\/jats:italic>\u2010511 and <jats:italic>TNF\u2010A\u2010<\/jats:italic>308 biallelic polymorphism were genotyped by 5\u2032 nuclease polymerase chain reaction (PCR) assays, and PCR\u2010restriction fragment length polymorphism (PCR\u2010RFLP). <jats:italic>IL\u20101RN<\/jats:italic> penta\u2010allelic variable number of tandem repeats was genotyped by PCR.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was no difference in the genetic polymorphism of <jats:italic>IL\u20101\u0392<\/jats:italic>\u2010511, <jats:italic>IL\u20101RN<\/jats:italic> and <jats:italic>TNF\u2010A<\/jats:italic> in the patients with gastric cancer regardless of <jats:italic>H. pylori<\/jats:italic> positivity compared with control. However, the frequencies of <jats:italic>IL\u20101B<\/jats:italic>\u2010511 C\/T (OR: 0.5, 95% CI: 0.3\u20130.7) and T carrier (OR: 0.6, 95% CI: 0.4\u20130.8) were lower in the <jats:italic>H. pylori<\/jats:italic>\u2010positive BGU patients. The <jats:italic>IL\u20101RN<\/jats:italic> 2\/2 was higher (OR: 5.5, 95% CI: 1.1\u201328.5) in the <jats:italic>H. pylori<\/jats:italic>\u2010positive GCR. There was no significance in the polymorphism of <jats:italic>TNF\u2010\u0391<\/jats:italic>\u2010308 regardless of <jats:italic>H. pylori<\/jats:italic>\u2010induced gastroduodenal diseases.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The <jats:italic>IL\u20101\u0392<\/jats:italic>\u2010511 T\u2010carrier polymorphism has a negative effect on the development of <jats:italic>H. pylori<\/jats:italic>\u2010positive BGU, and high frequency of <jats:italic>IL\u20101RN<\/jats:italic> 2\/2 was found in the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive relatives of GC patients, which suggest that this genetic polymorphism could play some role in the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010induced gastroduodenal diseases in Korea.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2006.00384.x","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T14:32:27Z","timestamp":1141828347000},"page":"105-112","source":"Crossref","is-referenced-by-count":44,"title":["The Effects of Genetic Polymorphisms of <i>IL\u20101<\/i> and <i>TNF\u2010A<\/i> on <i>Helicobacter pylori<\/i>\u2013Induced Gastroduodenal Diseases in Korea"],"prefix":"10.1111","volume":"11","author":[{"given":"Nayoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Il","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Yoon","family":"Yim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Mogg","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong 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