{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:44:19Z","timestamp":1778964259715,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Primary gastric low\u2010grade B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT lymphoma) is known to be successfully treated with anti\u2010<jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>) therapy alone. However, there are few reports on long\u2010term results after eradication therapy. The aims of this study were to analyze the rate and the interval to reach complete remission (CR), and to assess the rate and the factors affecting recurrence of MALT lymphoma.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Between 1996 and 2003, a total of 90\u00a0<jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected patients with low\u2010grade MALT lymphoma were included in this study. For initial staging, endoscopic ultrasonography, chest\u2013abdomen\u2013pelvis CT scans, and bone marrow examination were taken. All patients were made to take anti\u2010<jats:italic>H.\u00a0pylori<\/jats:italic> therapy for 14\u00a0days. Tumoral response was assessed by endoscopy every 3\u00a0months till CR and every 6\u00a0months after achieving CR.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Among 90 treated patients, 85 (94.4%) reached CR. The median interval to CR was 3\u00a0months (range, 1\u201324). Seventy\u2010nine (92.9%) patients were in CR at 12\u00a0months. Median follow\u2010up period after CR was 45\u00a0months (range 15\u2013109). Among 77 patients who were followed\u2010up after CR, 8 (10.4%) patients were proved with recurrence of MALT lymphoma. Cumulative recurrence rate was 2.7, 11.5, and 12.2% at 1, 2, and 3\u00a0years. The presence of <jats:italic>H.\u00a0pylori<\/jats:italic> was only a significant risk factor affecting recurrence.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The status of <jats:italic>H.\u00a0pylori<\/jats:italic> is the most important risk factor affecting recurrence. Therefore, adequate eradication regimen and accurate regular evaluation for <jats:italic>H.\u00a0pylori<\/jats:italic> status are needed during follow up of primary gastric low\u2010grade B\u2010cell MALT lymphoma.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2006.00460.x","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T20:25:07Z","timestamp":1162499107000},"page":"569-573","source":"Crossref","is-referenced-by-count":50,"title":["A Prospective Analysis of Low\u2010Grade Gastric MALT Lymphoma after <i>Helicobacter pylori<\/i> Eradication"],"prefix":"10.1111","volume":"11","author":[{"given":"Seong Soo","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwoon\u2010Yong","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Don","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho June","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gin Hyug","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hoon","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Yun","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu\u2010Jong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Sik","family":"Byeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jae","family":"Myung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Kyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weon\u2010Seon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Il","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,2]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70028-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.49.1.289"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19579"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.34"},{"key":"e_1_2_5_10_2","first-page":"609","article-title":"Treatment of low\u2010grade gastric mucosa\u2010associated lymphoid tissue lymphoma in stage I with Helicobacter pylori eradication. 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