{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:32Z","timestamp":1791229472742,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Chronic <jats:italic>Helicobacter pylori<\/jats:italic> infection is the most common cause of gastric cancer. <jats:italic>H.\u00a0pylori<\/jats:italic> induces oxidative stress while zinc deficiency results in increased sensitivity to it. In Ecuador, the prevalence of gastric cancer and zinc deficiency are high. We hypothesized that zinc deficiency in Ecuadorian people would cause increased <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010induced inflammation in the gastric mucosa associated with lower tissue zinc concentrations.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Three hundred and fifty\u2010two patients with dyspepsia underwent endoscopy to obtain gastric mucosa biopsies. Diagnosis of <jats:italic>H.\u00a0pylori<\/jats:italic> infection and its severity, histopathology, mucosal zinc concentration, and inflammation intensity were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected patients with non\u2010atrophic chronic gastritis had lower concentrations of zinc in gastric mucosa than uninfected patients with the same type of gastritis (251.3\u00a0\u00b1\u00a0225.3 vs. 426.2\u00a0\u00b1\u00a0279.9\u00a0ng\/mg of protein; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.016). Considering all patients, the more severe the <jats:italic>H.\u00a0pylori<\/jats:italic> infection, the higher the percentage of subjects with infiltration by polymorphonuclear (PMN) cells (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.0001). Patients with high PMN infiltration had lower mucosal zinc concentrations than patients with low PMN infiltration (35.2\u00a0\u00b1\u00a020.7 vs. 242.9\u00a0\u00b1 191.8\u00a0ng\/mg of protein; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.021).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The degree of inflammation in <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010induced gastritis appears to be modulated by gastric tissue zinc concentrations.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00476.x","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:15:35Z","timestamp":1168906535000},"page":"43-48","source":"Crossref","is-referenced-by-count":33,"title":["Low Concentrations of Zinc in Gastric Mucosa are Associated with Increased Severity of <i>Helicobacter pylori<\/i>\u2010Induced Inflammation"],"prefix":"10.1111","volume":"12","author":[{"given":"Fernando","family":"Semp\u00e9rtegui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mej\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo 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