{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:58:58Z","timestamp":1778176738402,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T00:00:00Z","timestamp":1168819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Improvement in platelet counts has been reported after eradication of <jats:italic>Helicobacter pylori<\/jats:italic> in patients with idiopathic thrombocytopenic purpura (ITP). We examined the levels of serum markers of gastritis and anti\u2010CagA (cytotoxin\u2010associated gene A) IgG antibody in patients with ITP to investigate whether these factors are associated with the platelet response after <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold> One hundred and sixteen consecutive patients with ITP were assessed for <jats:italic>H.\u00a0pylori<\/jats:italic> infection by <jats:sup>13<\/jats:sup>C\u2010urea breath test and serum <jats:italic>H.\u00a0pylori<\/jats:italic> antibody test. Patients with <jats:italic>H.\u00a0pylori<\/jats:italic> infection received eradication therapy. Before and after eradication therapy, we evaluated serum levels of gastrin, pepsinogen (PG)\u2010I, and PG\u2010II and the anti\u2010CagA IgG antibody titer.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>  <jats:italic>H.\u00a0pylori<\/jats:italic> infection was found in 67 (58%) of the 116 patients with ITP. Fifty\u2010two infected patients received eradication therapy, which was successful in 44 patients (85%). Twenty\u2010seven patients (62%) showed an increased platelet count and were identified as responders. The duration of ITP was shorter in responders than in nonresponders (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.017). There was no difference of the levels of gastrin and PGs between responders and nonresponders. Before eradication therapy, the serum anti\u2010CagA antibody titer did not differ significantly between responders and nonresponders. However, reduction in the anti\u2010CagA antibody titer after eradication therapy was significantly greater in responders than in nonresponders (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.013).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy improves the platelet count in <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients with ITP of short duration. Immune response of hosts to CagA protein of <jats:italic>H.\u00a0pylori<\/jats:italic> may play a role in the pathogenesis of ITP.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00477.x","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:15:35Z","timestamp":1168906535000},"page":"36-42","source":"Crossref","is-referenced-by-count":53,"title":["Immune Response to CagA Protein is Associated with Improved Platelet Count After <i>Helicobacter pylori<\/i> Eradication in Patients with Idiopathic Thrombocytopenic Purpura"],"prefix":"10.1111","volume":"12","author":[{"given":"Michiyo","family":"Kodama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Kai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingo","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70161-7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199806000-00008"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01974.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60004-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.812"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03612.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00277-002-0579-8","article-title":"Platelet 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