{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:58:57Z","timestamp":1778176737944,"version":"3.51.4"},"reference-count":96,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T00:00:00Z","timestamp":1178236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>Association between<jats:italic>Helicobacter pylori<\/jats:italic>and idiopathic thrombocytopenic purpura (ITP) has been found in Japan and in some European countries. It has also been shown that eradication of<jats:italic>H.\u00a0pylori<\/jats:italic>can increase platelet counts in patients with ITP. The aims of this study were to determine the prevalence of<jats:italic>H.\u00a0pylori<\/jats:italic>infection in patients with ITP in Colombia, and the effect of bacterial eradication on their platelet counts.<\/jats:p><jats:p><jats:bold>Materials and methods:\u2002<\/jats:bold>Between December 1998 and April 2006, a total of 32 patients diagnosed with ITP were included in the study. Controls were age and sex matched.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold><jats:italic>H.\u00a0pylori<\/jats:italic>infection in patients with ITP was significantly higher (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.00006) than in control individuals (90.6% and 43.8%, respectively), as determined by<jats:sup>13<\/jats:sup>C\u2010urea breath test. A significant association between<jats:italic>H.\u00a0pylori<\/jats:italic>infection and ITP was found (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0003), with an odds ratio (OR) of 13.15 (95%CI: 3.24\u201353.29). Multivariate analysis for the association between<jats:italic>H.\u00a0pylori<\/jats:italic>and ITP showed an OR of 20.44 (95%CI: 3.88\u2013107.49) for women and 19.28 (95%CI: 2.03\u2013183.42) for individuals over 50\u00a0years. All 29<jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients with ITP received eradication treatment. After a median follow up of 12.2\u00a0months, 80.8% had a recovery in platelet counts.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>According to these results and others from different countries where<jats:italic>H.\u00a0pylori<\/jats:italic>infection rates are high, patients with ITP should be initially tested for<jats:italic>H.\u00a0pylori<\/jats:italic>status, and if present, infection should be eradicated before initiating a drastic conventional ITP treatment. An algorithm for the study and management of patients with ITP in the post\u2010<jats:italic>Helicobacter<\/jats:italic>era is presented.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00502.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T06:02:51Z","timestamp":1178690571000},"page":"265-273","source":"Crossref","is-referenced-by-count":31,"title":["Proof of an Association between<i>Helicobacter pylori<\/i>and Idiopathic Thrombocytopenic Purpura in Latin America"],"prefix":"10.1111","volume":"12","author":[{"given":"Germ\u00e1n","family":"Campuzano\u2010Maya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-405X.2006.00430.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.30252.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.9.1349"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00441.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246068"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2005.06.015"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01284.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.04.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199806000-00008"},{"key":"e_1_2_6_12_2","first-page":"817","article-title":"The infection by Helicobacter pylori strains expressing CagA is highly prevalent in women with autoimmune thyroid disorders","volume":"50","author":"Figura N","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60004-9"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.812"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.363010.x"},{"key":"e_1_2_6_16_2","first-page":"1177","article-title":"Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura","volume":"87","author":"Veneri D","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100400015153"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.09.014"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093648"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537100500462487"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03612.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00277-002-0579-8","article-title":"Platelet recovery after eradication of Helicobacter pylori in patients with idiopathic thrombocytopenic purpura","volume":"82","author":"Hino M","year":"2003","journal-title":"Ann Hematol"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983220"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02983780"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00220.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04735.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.17.1904"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00261.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.04146"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01471.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41641.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-005-1071-z"},{"key":"e_1_2_6_33_2","first-page":"1436","article-title":"Effects of a Helicobacter pylori eradication regimen on anti\u2010platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura","volume":"91","author":"Asahi A","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00477.x"},{"key":"e_1_2_6_35_2","unstructured":"Rep\u00fablica de Colombia Salud Md. 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