{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:23:08Z","timestamp":1792804988382,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background:\u2002<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a major risk factor for atrophic gastritis and gastric cancer. Various extragastric manifestations of\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    infection have also recently been suggested. However, the correlation between\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    and colorectal cancer (CRC) is controversial. The aim of this study was to examine the correlation between\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    , serum gastrin level, and atrophic gastritis with CRC.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and methods:\u2002<\/jats:bold>\n                    Subjects were patients with CRC; controls were participants of a health check\u2010up program that was conducted between October 1998 and March 2002 at four hospitals in Nagano Prefecture. For 121 newly diagnosed CRC cases, two controls matched by age (within 3 years), gender, and residence were randomly selected from the program participants. We conducted questionnaires and obtained blood samples from the cases and their controls. Consequently, the CRC cancer pairs consisted of 113 cases and 226 controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Neither\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    infection nor gastrin level nor atrophic gastritis showed any association with a risk for CRC. However, serologically determined atrophic gastritis demonstrated significant elevation in odds ratios (ORs) for rectal cancer (OR\u00a0=\u00a03.15, 95% confidence interval; 1.19\u20138.35).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:\u2002<\/jats:bold>\n                    Gastric conditions such as chronic\n                    <jats:italic>H.\u00a0pylori<\/jats:italic>\n                    infection and atrophic gastritis are unlikely to increase the risk for CRC, although atrophic gastritis may increase the risk of rectal cancer.\n                  <\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00513.x","type":"journal-article","created":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T03:53:22Z","timestamp":1185767602000},"page":"328-332","source":"Crossref","is-referenced-by-count":49,"title":["Atrophic Gastritis,\n                    <i>Helicobacter pylori<\/i>\n                    , and Colorectal Cancer Risk: A Case\u2010Control Study"],"prefix":"10.1111","volume":"12","author":[{"given":"Ai","family":"Machida\u2010Montani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Sasazuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syusuke","family":"Natsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Shaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kasuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Tsugane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990095"},{"key":"e_1_2_6_3_2","first-page":"683","article-title":"Role of Helicobacter pylori infection in extragastriduodenal disorders: introductory remarks","volume":"50","author":"Konturek SJ","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90572-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/oxfordjournals.aje.a112399","article-title":"Correlations of incidence rates for selected cancers in the nine areas of the Third National Cancer Survey","volume":"105","author":"Winkelstein W","year":"1977","journal-title":"Am J Epidemiol"},{"key":"e_1_2_6_6_2","first-page":"585","article-title":"Correlations between cancer incidence rates from the Canadian National Center Incidence Reporting System, 1969\u201378","volume":"72","author":"Howe GR","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_7_2","unstructured":"Statistics and Information Department Minister's Secretariat Ministry of Health and Welfare.Age\u2010Adjusted Death Rates by Prefecture. 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