{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:27:56Z","timestamp":1787941676071,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The persistence of chronic inflammation in gastric mucosa and elevated <jats:italic>Helicobacter\u00a0pylori<\/jats:italic> antibodies after successful eradication therapy are common findings in clinical practice. We studied their possible association with each other and disappearance in long\u2010term follow up, as well as their possible connection with gastric atrophy.<\/jats:p><jats:p><jats:bold>Patients and methods:\u2002<\/jats:bold> The study population consisted of 108 dyspeptic patients with successful eradication therapy median 6.4\u00a0years earlier. The patients underwent gastroscopy, and biopsies from antrum and corpus were evaluated by an experienced pathologist. Serum samples collected from 77 patients were studied for <jats:italic>H.\u00a0pylori<\/jats:italic> antibodies, parietal cell antibodies, as well as for pepsinogen I, pepsinogen II, and gastrin\u201017 levels.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The prevalence of chronic gastric inflammation and elevated <jats:italic>H.\u00a0pylori<\/jats:italic> antibodies after successful eradication therapy decreased by time, but still after 5 years, 17 of 51 (33%) subjects had elevated <jats:italic>H.\u00a0pylori<\/jats:italic> antibodies and 14 of 68 (21%) had a mild inactive chronic inflammation in gastric mucosa. In patients with and without chronic inflammation in gastric mucosa, elevated <jats:italic>H.\u00a0pylori<\/jats:italic> antibodies were detected in three of 10 (30%) and 14 of 41 (34%), elevated parietal cell antibodies in one of 10 (10%) and six of 41 (15%), low pepsinogen I in one of 10 (10%) and none of 41, and elevated gastrin\u201017 in three of 10 (30%) and six of 41 (15%), respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> More than 5\u00a0years after successful <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy, mild persistent chronic inflammation may occur in gastric mucosa in up to one\u2010fifth and elevated <jats:italic>H.\u00a0pylori<\/jats:italic> antibodies even in one\u2010third of patients, although these two are independent phenomena.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00549.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T13:16:03Z","timestamp":1284556563000},"page":"605-608","source":"Crossref","is-referenced-by-count":22,"title":["Persisting Chronic Gastritis and Elevated <i>Helicobacter pylori<\/i> Antibodies after Successful Eradication Therapy"],"prefix":"10.1111","volume":"12","author":[{"given":"Lea","family":"Veijola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Oksanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auli","family":"Linnala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pentti","family":"Sipponen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilpi","family":"Rautelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.072009"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199905)188:1<24::AID-PATH316>3.0.CO;2-F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00134-X"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90929-W"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-004-1157-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2004.10.002"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.037"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/JCM.36.4.955-957.1998","article-title":"Evaluation of Pyloriset Screen, a rapid whole\u2010blood diagnostic test for Helicobacter pylori infection","volume":"36","author":"Oksanen A","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200308000-00009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00604.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.066"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.2.187"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1523-5378.2007.00549.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1523-5378.2007.00549.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T18:39:46Z","timestamp":1697135986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1523-5378.2007.00549.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,12]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1523-5378.2007.00549.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1523-5378.2007.00549.x","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,12]]}}}