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The main aim of this article is to review the evolution of <jats:italic>H.\u00a0pylori<\/jats:italic> therapy from a meta\u2010analytical perspective. Initially, antibiotic monotherapy had a minor efficacy on <jats:italic>H.\u00a0pylori<\/jats:italic>. Dual therapy including either bismuth compounds or proton\u2010pump inhibitors (PPI) and one antibiotic also resulted in insufficient cure rates. Bismuth\u2010based triple therapy (the first used) and PPI\u2010based triple therapies (combined with two antibiotics, including amoxicillin, nitroimidazole, or clarithromycin) have been the most widely recommended. PPI\u2010based regimens are superior to H<jats:sub>2<\/jats:sub>\u2010antagonist\u2013based ones. The influence of the type of PPI, the dose and the duration of the treatment will be discussed. Among the factors influencing the efficacy of therapy, resistance to clarithromycin and metronidazole are the most important risk factors for eradication failure. Several rescue therapies can be used. Bismuth\u2010based quadruple therapy is effective, but the complexity of the regimen and the associated adverse effects limit the compliance. PPI\u2010based triple therapy with amoxicillin and levofloxacin is at least equally effective and better tolerated.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2007.00576.x","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T06:10:58Z","timestamp":1194415858000},"page":"50-58","source":"Crossref","is-referenced-by-count":63,"title":["Evolution of <i>Helicobacter pylori<\/i> Therapy from a Meta\u2010analytical Perspective"],"prefix":"10.1111","volume":"12","author":[{"given":"Javier P.","family":"Gisbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Pajares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Pajares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,6]]},"reference":[{"key":"e_1_2_10_2_2","first-page":"105","volume-title":"Helicobacter Pioneers. 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