{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:36:08Z","timestamp":1793975768624,"version":"4.8.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T00:00:00Z","timestamp":1200268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2003<\/jats:bold> Peptic ulcers and erosions (PU&amp;E) are thought to be uncommon in children. Patients with early exposure to <jats:italic>Helicobacter pylori<\/jats:italic> may be at a higher risk for early onset PU&amp;E. Children in Israel have a high prevalence and early acquisition of <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H.\u00a0pylori<\/jats:italic>) and have easy access to pediatric gastroenterologists and endoscopy. Our aim was to describe the prevalence and characteristics of PU&amp;E in this population referred by Pediatric Gastroenterologists for an upper endoscopy.<\/jats:p><jats:p><jats:bold>Methods:\u2003<\/jats:bold> We conducted a retrospective study over the years January 2003\u2013May 2006. Over these years we had information on 751 diagnostic upper endoscopies. PU&amp;E was regarded as erosive gastritis\/duodenitis or ulcer in either the stomach or duodenum. <jats:italic>H.\u00a0pylori<\/jats:italic> status was assessed using rapid urease test and gastric biopsies.<\/jats:p><jats:p><jats:bold>Results:\u2003<\/jats:bold> PU&amp;E was detected in 169 (22.5%) patients (ulcers 51 (6.8%), erosions 118 (15.7%)). One hundred twenty\u2010four had gastric PU&amp;E and 58 had duodenal PU&amp;E. <jats:italic>H.\u00a0pylori<\/jats:italic> was positive in 112 (66.3%). <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010associated PU&amp;E becomes common after age 10\u00a0years, with gastric PU&amp;E presenting much earlier than duodenal disease. Most of the <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010negative PU&amp;E were idiopathic and improved symptomatically on PPI treatment. Interestingly, 43% of patients with PU&amp;E in our cohort were either immigrants from the former Soviet Union or of Israeli Arab origin.<\/jats:p><jats:p><jats:bold>Conclusions:\u2003<\/jats:bold> PU&amp;E appears to be common in this selected population with a relatively high incidence of gastric PU&amp;E. <jats:italic>H.\u00a0pylori<\/jats:italic> associated PU&amp;E becomes common after age 10\u00a0years with gastric PU&amp;E presenting much earlier than duodenal disease. Non <jats:italic>H.\u00a0pylori<\/jats:italic> PU&amp;E in children comprises approximately a third of all PU&amp;E, are mostly idiopathic and appear earlier than <jats:italic>H.\u00a0pylori<\/jats:italic> associated PU&amp;E.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2008.00570.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T13:10:37Z","timestamp":1284556237000},"page":"62-68","source":"Crossref","is-referenced-by-count":39,"title":["Peptic Ulcers and Erosions Are Common in Israeli Children Undergoing Upper 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