{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:01:44Z","timestamp":1761919304774},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T00:00:00Z","timestamp":1267574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background and Aims:\u2002<\/jats:bold> The eradication rate of proton\u2010pump inhibitor\u2010based triple therapy for <jats:italic>Helicobacter pylori<\/jats:italic> infection is low due to increasing antibiotics resistance, especially clarithromycin. Recently, it was reported in Europe that a 10\u2010day sequential strategy produced good outcomes. The aim of this study was to assess the efficacy of sequential therapy as first\u2010line treatment for eradication of <jats:italic>H. pylo<\/jats:italic>ri in clinical practice in Korea.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> A total of 98 patients (mean age 55.2\u2003years and male 47, female 51) with proven <jats:italic>H. pylori<\/jats:italic> infection received 10\u2010day sequential therapy (20\u2003mg of rabeprazole, and 1\u2003g of amoxicillin, twice daily for the first 5\u2003days, followed by 20\u2003mg of rabeprazole, 500\u2003mg of clarithromycin, and 500\u2003mg of metronidazole, twice daily for the remaining 5\u2003days). Eradication was evaluated 4\u2003weeks later, after completion of treatment by 13<jats:sup>C<\/jats:sup>\u2010urea breath testing. Eradication rates were calculated by intention\u2010to\u2010treat (ITT) and by per protocol (PP). Compliance and adverse events were also assessed in study group.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The eradication rate of sequential therapy was 91.8% (90\/98) by ITT and same result was reported by PP analysis (89\/97). The study group consisted of 66 <jats:italic>H. pylori<\/jats:italic> associated gastritis, 7 gastric ulcer, and 25 duodenal ulcer patients (67.3%, 7.1%, 25.5%, respectively). Mild adverse events happened frequently (21.4%) but the treatment was well tolerable. The most common adverse event was a bitter taste (9.2%) followed by nausea and diarrhea (4.1%).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Ten\u2010day sequential therapy is found to effectively eradicate <jats:italic>H. pylori<\/jats:italic> infection as first\u2010line treatment in Korea.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2010.00748.x","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T07:16:12Z","timestamp":1267600572000},"page":"148-153","source":"Crossref","is-referenced-by-count":37,"title":["Ten\u2010Day Sequential Therapy as First\u2010line Treatment for <i>Helicobacter pylori<\/i> Infection in Korea: A Retrospective Study"],"prefix":"10.1111","volume":"15","author":[{"given":"Jung H.","family":"Kwon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong 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