{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:37:03Z","timestamp":1767926223314,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> causes gastritis, peptic ulcer and is a risk factor for adenocarcinoma and lymphoma of the stomach. Gastric mucins, carrying highly diverse carbohydrate structures, present functional binding sites for <jats:italic>H. pylori<\/jats:italic> and may play a role in pathogenesis. However, little information is available regarding gastric mucin in children with and without stomach diseases.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Expression of mucins and glycosylation was studied by immunohistochemistry on gastric biopsies from 51 children with and without <jats:italic>H. pylori<\/jats:italic> infection and\/or peptic ulcer disease.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In all children, MUC5AC was present in the surface epithelium and MUC6 in the glands. No MUC6 in the surface epithelium or MUC2 was detected in any section. The Le<jats:sup>b<\/jats:sup> and Le<jats:sup>a<\/jats:sup> blood group antigens were present in the surface epithelium of 80% and 29% of children, respectively. <jats:italic>H. pylori<\/jats:italic> load was higher in Le<jats:sup>b<\/jats:sup> negative children than in Le<jats:sup>b<\/jats:sup> positive individuals (mean\u2003\u00b1\u2003SEM 17.8\u2003\u00b1\u20033.5 vs 10.8\u2003\u00b1\u20031.5; <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), but there was no correlation between Le<jats:sup>a<\/jats:sup> or Le<jats:sup>b<\/jats:sup> status and gastritis, nodularity, and gastric or duodenal ulcer (DU). Expression of sialyl\u2010Le<jats:sup>x<\/jats:sup> was associated with <jats:italic>H. pylori<\/jats:italic> infection, and DU.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Mucin expression and glycosylation is similar in children and adults. However, in contrast to adults, pediatric <jats:italic>H. pylori<\/jats:italic> infection is not accompanied by aberrant expression of MUC6 or MUC2. Furthermore, the lower <jats:italic>H. pylori<\/jats:italic> density in Le<jats:sup>b<\/jats:sup> positive children indicates that <jats:italic>H. pylori<\/jats:italic> is suppressed in the presence of gastric mucins decorated with Le<jats:sup>b<\/jats:sup>, the binding site of the <jats:italic>H. pylori<\/jats:italic> BabA adhesin.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2010.00765.x","type":"journal-article","created":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T04:35:44Z","timestamp":1279254944000},"page":"251-258","source":"Crossref","is-referenced-by-count":38,"title":["Role of Mucin Lewis Status in Resistance to <i>Helicobacter pylori<\/i> Infection in Pediatric Patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Sara","family":"Lind\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Semino\u2010Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Rick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100125"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200208002-00010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.1.10"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"e_1_2_6_6_2","first-page":"1903","article-title":"Key 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