{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:45:33Z","timestamp":1758123933254},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1567,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1111\/j.1523-5378.2011.00824.x","type":"journal-article","created":{"date-parts":[[2011,5,18]],"date-time":"2011-05-18T09:01:24Z","timestamp":1305709284000},"page":"189-199","source":"Crossref","is-referenced-by-count":14,"title":["Helicobacter pylori Exhibits a Fur-Dependent Acid Tolerance Response"],"prefix":"10.1111","volume":"16","author":[{"given":"Manuel","family":"Valenzuela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Albar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Paradela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,18]]},"reference":[{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1128\/jb.177.14.4097-4104.1995","article-title":"Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coli","volume":"177","author":"Lin","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1086\/315855","article-title":"Identification of loci essential for the growth of Helicobacter pylori under acidic conditions","volume":"182","author":"Bijlsma","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1128\/IAI.70.2.606-611.2002","article-title":"The Helicobacter pylori homologue of the ferric uptake regulator is involved in acid resistance","volume":"70","author":"Bijlsma","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-2911(08)60147-2","article-title":"Molecular responses of microbes to environmental pH stress","volume":"37","author":"Hall","year":"1995","journal-title":"Adv Microb Physiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB5|cit5","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CMR.10.4.720","article-title":"Helicobacter pylori","volume":"10","author":"Dunn","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/0016-5085(87)90619-6","article-title":"pH of the microclimate lining human gastric and duodenal mucosa in vivo. Studies in control subjects and in duodenal ulcer patients","volume":"92","author":"Quigley","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0016-5085(94)90075-2","article-title":"Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa","volume":"107","author":"Schade","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(86)91060-3","article-title":"Urea hydrolysis in patients with Campylobacter pyloridis infection","volume":"1","author":"Marshall","year":"1986","journal-title":"Lancet"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1128\/JCM.26.5.831-836.1988","article-title":"Characterization of urease from Campylobacter pylori","volume":"26","author":"Mobley","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/gut.40.1.25","article-title":"Synthesis and activity of Helicobacter pylori urease and catalase at low pH","volume":"40","author":"Bauerfeind","year":"1997","journal-title":"Gut"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.physiol.65.092101.142156","article-title":"The gastric biology of Helicobacter pylori","volume":"65","author":"Sachs","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1126\/science.287.5452.482","article-title":"A H+-gated urea channel: the link between Helicobacter pylori urease and gastric colonization","volume":"287","author":"Weeks","year":"2000","journal-title":"Science"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1128\/IAI.72.2.766-773.2004","article-title":"Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade","volume":"72","author":"van Vliet","year":"2004","journal-title":"Infect Immun"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1086\/515606","article-title":"Acid-tolerance response in Helicobacter pylori and differences between cagA+ and cagA- strains","volume":"178","author":"Karita","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-6968.1998.tb13244.x","article-title":"Urease-positive, acid-sensitive mutants of Helicobacter pylori: urease-independent acid resistance involved in growth at low pH","volume":"167","author":"Bijlsma","year":"1998","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1574-6968.2002.tb11287.x","article-title":"Acid stress response in Helicobacter pylori","volume":"213","author":"Toledo","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/ajcp\/94.2.187","article-title":"The gastric juice urea and ammonia levels in patients with Campylobacter pylori","volume":"94","author":"Kim","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/jb.172.2.771-778.1990","article-title":"Adaptive acidification tolerance response of Salmonella typhimurium","volume":"172","author":"Foster","year":"1990","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2958.1995.mmi_17010155.x","article-title":"The stationary-phase sigma factor sigma S (RpoS) is required for a sustained acid tolerance response in virulent Salmonella typhimurium","volume":"17","author":"Lee","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1128\/JB.182.8.2245-2252.2000","article-title":"OmpR regulates the stationary-phase acid tolerance response of Salmonella enterica serovar typhimurium","volume":"182","author":"Bang","year":"2000","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1128\/JB.180.9.2409-2417.1998","article-title":"A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress","volume":"180","author":"Bearson","year":"1998","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1128\/jb.178.19.5683-5691.1996","article-title":"The role of fur in the acid tolerance response of Salmonella typhimurium is physiologically and genetically separable from its role in iron acquisition","volume":"178","author":"Hall","year":"1996","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0378-1097(03)00423-3","article-title":"Helicobacter pylori strain ATCC700392 encodes a methyl-accepting chemotaxis receptor protein (MCP) for arginine and sodium bicarbonate","volume":"224","author":"Cerda","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0378-1119(90)90463-2","article-title":"Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction","volume":"94","author":"Wang","year":"1990","journal-title":"Gene"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1128\/JB.181.18.5572-5580.1999","article-title":"HP0333, a member of the dprA family, is involved in natural transformation in Helicobacter pylori","volume":"181","author":"Ando","year":"1999","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/0092-8674(77)90176-3","article-title":"High resolution two-dimensional electrophoresis of basic as well as acidic proteins","volume":"12","author":"O\u2019Farrell","year":"1977","journal-title":"Cell"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal Chem"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1078\/1438-4221-00106","article-title":"Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria","volume":"291","author":"Audia","year":"2001","journal-title":"Int J Med Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1128\/jb.175.7.1981-1987.1993","article-title":"The acid tolerance response of Salmonella typhimurium involves transient synthesis of key acid shock proteins","volume":"175","author":"Foster","year":"1993","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1128\/jb.173.21.6896-6902.1991","article-title":"Salmonella acid shock proteins are required for the adaptive acid tolerance response","volume":"173","author":"Foster","year":"1991","journal-title":"J Bacteriol"},{"issue":"Pt 8","key":"10.1111\/j.1523-5378.2011.00824.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1099\/00221287-147-8-2285","article-title":"Characterization of the low-pH responses of Helicobacter pylori using genomic DNA arrays","volume":"147","author":"Allan","year":"2001","journal-title":"Microbiology"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1128\/IAI.69.3.1679-1686.2001","article-title":"Acid-induced gene expression in Helicobacter pylori: study in genomic scale by microarray","volume":"69","author":"Ang","year":"2001","journal-title":"Infect Immun"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1128\/IAI.71.6.3529-3539.2003","article-title":"pH-regulated gene expression of the gastric pathogen Helicobacter pylori","volume":"71","author":"Merrell","year":"2003","journal-title":"Infect Immun"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1046\/j.1365-2958.2000.01896.x","article-title":"Comparative proteome analysis of Helicobacter pylori","volume":"36","author":"Jungblut","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2958.2004.04137.x","article-title":"Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori","volume":"53","author":"Bury-Mone","year":"2004","journal-title":"Mol Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/BJ20090434","article-title":"Helicobacter pylori UreE, a urease accessory protein: specific Ni(2\u2003+\u2003)- and Zn(2\u2003+\u2003)-binding properties and interaction with its cognate UreG","volume":"422","author":"Bellucci","year":"2009","journal-title":"Biochem J"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1128\/IAI.63.6.2213-2220.1995","article-title":"Characterization of a Helicobacter pylori neutrophil-activating protein","volume":"63","author":"Evans","year":"1995","journal-title":"Infect Immun"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1574-695X.1996.tb00220.x","article-title":"Helicobacter pylori utilises urea for amino acid synthesis","volume":"13","author":"Williams","year":"1996","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1074\/mcp.M800160-MCP200","article-title":"In vivo interactome of Helicobacter pylori urease revealed by tandem affinity purification","volume":"7","author":"Stingl","year":"2008","journal-title":"Mol Cell Proteomics"},{"issue":"Pt 12","key":"10.1111\/j.1523-5378.2011.00824.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1099\/00221287-148-12-3827","article-title":"Growth phase-dependent and differential transcriptional control of flagellar genes in Helicobacter pylori","volume":"148","author":"Niehus","year":"2002","journal-title":"Microbiology"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijmm.2006.11.006","article-title":"Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling","volume":"297","author":"Ye","year":"2007","journal-title":"Int J Med Microbiol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1128\/JB.188.10.3449-3462.2006","article-title":"Characterization of the ArsRS regulon of Helicobacter pylori, involved in acid adaptation","volume":"188","author":"Pflock","year":"2006","journal-title":"J Bacteriol"},{"issue":"Pt 2","key":"10.1111\/j.1523-5378.2011.00824.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1099\/mic.0.27404-0","article-title":"Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression","volume":"151","author":"Ernst","year":"2005","journal-title":"Microbiology"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"16397","DOI":"10.1073\/pnas.0508032102","article-title":"Nucleoid remodeling by an altered HU protein: reorganization of the transcription program","volume":"102","author":"Kar","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1128\/jb.179.11.3494-3499.1997","article-title":"The Escherichia coli histone-like protein HU affects DNA initiation, chromosome partitioning via MukB, and cell division via MinCDE","volume":"179","author":"Jaffe","year":"1997","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1093\/emboj\/19.23.6527","article-title":"The histone-like protein HU binds specifically to DNA recombination and repair intermediates","volume":"19","author":"Kamashev","year":"2000","journal-title":"EMBO J"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1073\/pnas.94.13.6712","article-title":"Alterations of the outer membrane composition in Escherichia coli lacking the histone-like protein HU","volume":"94","author":"Painbeni","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1073\/pnas.92.9.3958","article-title":"Increased sensitivity to gamma irradiation in bacteria lacking protein HU","volume":"92","author":"Boubrik","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1128\/JB.01703-08","article-title":"Analysis of protein expression regulated by the Helicobacter pylori ArsRS two-component signal transduction system","volume":"192","author":"Loh","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB51|cit51","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1574-6968.1997.tb10238.x","article-title":"Acid stress responses in enterobacteria","volume":"147","author":"Bearson","year":"1997","journal-title":"FEMS Microbiol Lett"},{"key":"10.1111\/j.1523-5378.2011.00824.x-BIB52|cit52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-5378.2002.00088.x","article-title":"The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptake","volume":"7","author":"van Vliet","year":"2002","journal-title":"Helicobacter"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1523-5378.2011.00824.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1523-5378.2011.00824.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T22:17:35Z","timestamp":1625523455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1523-5378.2011.00824.x"}},"subtitle":["Fur-dependent Acid Response in H.\u00a0pylori"],"short-title":[],"issued":{"date-parts":[[2011,5,18]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1523-5378.2011.00824.x","relation":{},"ISSN":["1083-4389"],"issn-type":[{"value":"1083-4389","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,18]]}}}