{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:47:19Z","timestamp":1759938439310},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,3]],"date-time":"2012-01-03T00:00:00Z","timestamp":1325548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Sequential regimens have been recently reported to be superior to the standard triple therapies in <jats:italic>Helicobacter pylori<\/jats:italic> eradication, but most of these studies were performed in Europe and data from developing countries are lacking. So we designed a study to compare a sequential regimen with a bismuth\u2010based quadruple therapy that contains a short course of furazolidone, in Iran.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Two hundred and ninety\u2010six patients with duodenal ulcer and na\u00efve <jats:italic>H.\u00a0pylori<\/jats:italic> infection were randomized into two groups: 148 patients received (PAB\u2010F) pantoprazole (40\u2003mg\u2010bid), amoxicillin (1\u2003g\u2010bid), and bismuth subcitrate (240\u2003mg\u2010bid) for 2\u2003weeks and furazolidone (200\u2003mg\u2010bid) just during the first week. And 148 patients received (PA\u2010CT) pantoprazole (40\u2003mg\u2010bid) for 10\u2003days, amoxicillin (1\u2003g\u2010bid) for the first 5\u2003days, and clarithromycin (500\u2003mg\u2010bid) plus tinidazole (500\u2003mg\u2010bid) just during the second 5\u2003days. C<jats:sup>14<\/jats:sup>\u2010urea breath test was performed 8\u2003weeks after the treatment.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Two hundred and sixty\u2010one patients completed the study (137 patients in the PA\u2010CT and 124 in the PAB\u2010F group). The results were not statistically different between the two groups in the eradication rates and the severity of side effects. The intention to treat eradication rate was 80.4% in the PAB\u2010F group and 83.7% in the PA\u2010CT group. Per\u2010protocol eradication rates were 88.7% and 89.1%, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Because the two regimens showed acceptable and similar abilities in <jats:italic>H.\u00a0pylori<\/jats:italic> eradication and because of much higher cost of clarithromycin in Iran, the furazolidone containing regimen seems to be superior. Further modifications of sequential therapies are needed to make them ideal regimens in developing countries.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2011.00896.x","type":"journal-article","created":{"date-parts":[[2012,1,5]],"date-time":"2012-01-05T09:33:54Z","timestamp":1325756034000},"page":"43-48","source":"Crossref","is-referenced-by-count":21,"title":["A Comparison between Sequential Therapy and a Modified Bismuth\u2010based Quadruple Therapy for <i>Helicobacter pylori<\/i> Eradication in Iran: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Hafez","family":"Fakheri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarang","family":"Taghvaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahid","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Bari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00639.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.008"},{"key":"e_1_2_7_4_2","first-page":"200","article-title":"Clinical factors that potentially affect the treatment outcome of Helicobacter pylori eradication therapy with using a standard triple regimen in peptic ulcer patients","volume":"36","author":"Nam T","year":"2008","journal-title":"Korean J Gastrointest Endosc"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00008"},{"key":"e_1_2_7_7_2","first-page":"177","article-title":"Increase in resistance rates of H.\u00a0pylori isolates to metronidazole and tetracycline \u2013 comparison of three 3\u2010year studies","volume":"13","author":"Siavoshi F","year":"2010","journal-title":"Arch Iranian Med"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.555"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2008.00969.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-12-200806170-00226"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01924.x"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00748.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.09.030"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.708"},{"key":"e_1_2_7_15_2","first-page":"1419","article-title":"Effect of triple therapy or amoxycillin plus omeprazole or amoxycillin plus tinidazole plus omeprazole on duodenal ulcer healing, eradication of Helicobacter pylori, and prevention of ulcer relapse over a 1\u2010year follow\u2010up period: a prospective, randomized, controlled study","volume":"90","author":"Saberi\u2010Firoozi M","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_16_2","first-page":"PI105","article-title":"The efficacy of furazolidone\u2010based quadruple therapy for eradication of Helicobacter pylori infection in Iranian patients resistant to metronidazole\u2010based quadruple therapy","volume":"9","author":"Ebrahimi\u2010Dariani N","year":"2003","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05029.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-8-200704170-00006"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01461.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03174.x"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-6-200709180-00022"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02897.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.563"},{"key":"e_1_2_7_25_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MCG.0b013e3181c8a1a3","article-title":"Sequential therapy for Helicobacter pylori eradication: a critical review","volume":"44","author":"Gisbert JP","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-2-200601170-00006"},{"key":"e_1_2_7_27_2","first-page":"280","article-title":"[Effectiveness of 10\u2003day\u2010sequential therapy for Helicobacter pylori eradication in Korea]","volume":"51","author":"Choi WH","year":"2008","journal-title":"Korean J Gastroenterol"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(09)61556-0"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181acebef"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.215350"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(08)60120-1"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.00931.x"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.306-308.2001"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.6224"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.860"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2008.00649.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00640.x"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01822.x"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.58762"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00518.x"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.1.8"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2010.00795.x"}],"container-title":["Helicobacter"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1523-5378.2011.00896.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1523-5378.2011.00896.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T17:24:14Z","timestamp":1698686654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1523-5378.2011.00896.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,3]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1523-5378.2011.00896.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1523-5378.2011.00896.x","archive":["Portico"],"relation":{},"ISSN":["1083-4389","1523-5378"],"issn-type":[{"value":"1083-4389","type":"print"},{"value":"1523-5378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,3]]}}}