{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:55:26Z","timestamp":1769316926598,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic>\u2010infected children from coastal Tumaco, Colombia, have more parasitism, and adults have lower gastric cancer risk compared with high\u2010altitude Pasto\/Tuquerres residents. Because helminth and <jats:italic>Toxoplasma gondii<\/jats:italic> infections alter helicobacter gastritis in rodent models, we determined whether seropositivity to <jats:italic>Ascaris lumbricoides<\/jats:italic> or <jats:italic>T.\u00a0gondii<\/jats:italic> was associated with Th2\u2010IgG1 or Th1\u2010IgG2 responses to <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Sera (240) from the two populations were evaluated for <jats:italic>A.\u00a0lumbricoides<\/jats:italic> and <jats:italic>T.\u00a0gondii<\/jats:italic> seropositivity and results correlated with IgE and IgG isotype responses to <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Most Tumaco children and adults were seropositive for <jats:italic>A.\u00a0lumbricoides<\/jats:italic> (89%, 66%), <jats:italic>T.\u00a0gondii<\/jats:italic> (59%, 98%), or both (45%, 66%). In contrast, seropositivity among Pasto\/Tuquerres children was much lower (9%<jats:italic>A.\u00a0lumbricoides<\/jats:italic>, 11%<jats:italic>T.\u00a0gondii,<\/jats:italic> and 2% dual positive) but increased in adults (58%<jats:italic>A.\u00a0lumbricoides<\/jats:italic>, 82%<jats:italic>T.\u00a0gondii,<\/jats:italic> and 41% dual positive). <jats:italic>A.\u00a0lumbricoides<\/jats:italic> seropositivity correlated with elevated IgE and anti\u2010inflammatory Th2\u2010IgG1 responses to <jats:italic>H.\u00a0pylori<\/jats:italic>, while <jats:italic>T.\u00a0gondii<\/jats:italic><jats:italic>gondii<\/jats:italic> seropositivity was linked to elevated IgE, pro\u2010inflammatory Th1\u2010IgG2, IgG3, and IgG4 responses to <jats:italic>H.\u00a0pylori<\/jats:italic>. Individuals with high <jats:italic>T.\u00a0gondii<\/jats:italic> titers had reduced Th1\u2010IgG2, IgG3, and IgG4 responses to <jats:italic>H.\u00a0pylori<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Results support regional differences for childhood parasitism and indicate <jats:italic>A.\u00a0lumbricoides<\/jats:italic> and <jats:italic>T.\u00a0gondii<\/jats:italic> infections may impact inflammatory responses to <jats:italic>H.\u00a0pylori<\/jats:italic> and partially explain differences in gastric cancer risk in Colombia.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2011.00916.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T15:06:35Z","timestamp":1331219195000},"page":"107-115","source":"Crossref","is-referenced-by-count":28,"title":["Serologic Evidence that <i>Ascaris<\/i> and <i>Toxoplasma<\/i> Infections Impact Inflammatory Responses to <i>Helicobacter pylori<\/i> in Colombians"],"prefix":"10.1111","volume":"17","author":[{"given":"Courtney","family":"Ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark T.","family":"Whary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Ihrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis E.","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pelayo","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.07.010"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.4.429"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.728"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2010.00761.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.234468"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00475.2003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903401959"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.048"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506655103"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/75015"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.05.005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901215)66:12<2569::AID-CNCR2820661220>3.0.CO;2-I"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520252903044"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485909X398311"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2006.apm_392.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1083-4389.2004.00221.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008924"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0095"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/jnci\/57.5.1027","article-title":"Gastric cancer in Colombia. 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