{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:22:19Z","timestamp":1782289339006,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T00:00:00Z","timestamp":1331164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Background:\u2002<\/jats:bold> The most common complications of peptic ulcer are bleeding and perforation. In many regions, definitive acid reduction surgery has given way to simple closure and <jats:italic>Helicobacter pylori<\/jats:italic> eradication.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To perform a systematic review and meta\u2010analysis to ask whether this change in practice is in fact justified.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> A search on the Cochrane Controlled Trials Register, Medline, and Embase was made for controlled trials of duodenal ulcer perforation patients using simple closure method plus postoperative <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy <jats:italic>versus<\/jats:italic> simple closure plus antisecretory non\u2010eradication therapy. The long\u2010term results for prevention of ulcer recurrence were compared.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The pooled incidence of 1\u2010year ulcer recurrence in <jats:italic>H.\u00a0pylori<\/jats:italic> eradication group was 5.2% [95% confidence interval (CI) of 0.7 and 9.7], which is significantly lower than that of the control group (35.2%) with 95% CI of 0.25 and 0.45. The pooled relative risk was 0.15 with 95% CI of 0.06 and 0.37.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>  <jats:italic>Helicobacter pylori<\/jats:italic> eradication after simple closure of duodenal ulcer perforation gives better result than the operation plus antisecretory non\u2010eradication therapy for prevention of ulcer recurrence. All duodenal ulcer perforation patients should be tested for <jats:italic>H.\u00a0pylori<\/jats:italic> infection, and eradication therapy is required in all infected patients.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2011.00928.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T15:06:35Z","timestamp":1331219195000},"page":"148-152","source":"Crossref","is-referenced-by-count":21,"title":["Systematic Review and Meta\u2010Analysis: <i>Helicobacter pylori<\/i> Eradication Therapy After Simple Closure of Perforated Duodenal Ulcer"],"prefix":"10.1111","volume":"17","author":[{"given":"Prakitpunthu","family":"Tomtitchong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boonying","family":"Siribumrungwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratha\u2010Korn","family":"Vilaichone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petch","family":"Kasetsuwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathorn","family":"Chaiyakunapruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,8]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198801000-00002"},{"key":"e_1_2_7_3_2","first-page":"365","article-title":"Peptic ulcer disease before and after introduction of new drugs \u2013 a comparison from surgeon\u2019s point of view","volume":"6","author":"Janik J","year":"2000","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_4_2","first-page":"708","article-title":"Simple closure of peptic ulcer. 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