{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:17:42Z","timestamp":1789013862933,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> The prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> in Western populations has steadily decreased. This has been suggested as one of the factors involved in the recent increase of asthma and allergy. Some studies have reported a negative association between <jats:italic>H.\u00a0pylori<\/jats:italic> and asthma and allergy, but data are inconsistent and there are a few studies in children.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> We investigated whether the prevalence of <jats:italic>H.\u00a0pylori<\/jats:italic> was associated with asthma symptoms, allergic rhinitis, and atopic dermatitis in childhood.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We determined IgG anti\u2010<jats:italic>H.\u00a0pylori<\/jats:italic> and CagA antibodies in serum of Dutch children, who took part in the PIAMA birth cohort study. Serum was collected from 545 children, aged 7\u20139\u2003years (Dutch ethnicity 91.5%). Symptoms of asthma and atopy were assessed by yearly questionnaires. Chi\u2010square tests and logistic regression were used.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We found 9%<jats:italic>H.\u00a0pylori<\/jats:italic> and 0.9% CagA seropositivity. Twelve (5.9%) children with reported wheezing ever were <jats:italic>H.\u00a0pylori<\/jats:italic> positive, compared to 37 (10.9%) of the non\u2010wheezers (<jats:italic>p<\/jats:italic>\u2003=\u2003.05). No significant differences in <jats:italic>H.\u00a0pylori<\/jats:italic> prevalence were found between children with or without allergic rhinitis (8.5% vs 9.5%), atopic dermatitis (8.7% vs 9.2%), and physician\u2010diagnosed asthma (7.1% vs 9.4%). Multivariate analysis showed no significant associations between <jats:italic>H.\u00a0pylori<\/jats:italic> seropositivity and wheezing (OR 0.52; 95% CI 0.25\u20131.06), allergic rhinitis (OR 0.96; 95% CI 0.51\u20131.81), atopic dermatitis (OR 1.05; 95% CI 0.56\u20131.98) or physician\u2010diagnosed asthma (OR 0.87; 95% CI 0.37\u20132.08).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We found a borderline significantly lower <jats:italic>H.\u00a0pylori<\/jats:italic> seropositivity in children with wheezing compared to non\u2010wheezers, but no association between <jats:italic>H.\u00a0pylori<\/jats:italic> serum\u2010antibody status and allergic rhinitis, atopic dermatitis, or asthma.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2012.00934.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T10:48:12Z","timestamp":1332240492000},"page":"232-237","source":"Crossref","is-referenced-by-count":43,"title":["The Impact of <i>Helicobacter pylori<\/i> on Atopic Disorders in Childhood"],"prefix":"10.1111","volume":"17","author":[{"given":"I. Lisanne","family":"Holster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie J.","family":"Vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Caudri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"den Hoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo I.","family":"Perez\u2010Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan C.","family":"de Jongste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst 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