{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:07:07Z","timestamp":1774840027223,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Barium radiographic studies have suggested the importance of evaluating areae gastricae pattern for the diagnosis of gastritis. Significance of endoscopic appearance of areae gastricae in the diagnosis of chronic atrophic fundic gastritis (CAFG) was investigated by image\u2010enhanced endoscopy.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Endoscopic images of the corpus lesser curvature were studied in 50 patients with CAFG. Extent of CAFG was evaluated with autofluorescence imaging endoscopy. The areae gastricae pattern was evaluated with 0.2% indigo carmine chromoendoscopy. Micro\u2010mucosal structure was examined with magnifying chromoendoscopy and narrow band imaging.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In patients with small extent of CAFG, polygonal areae gastricae separated by a narrow intervening part of areae gastricae was observed, whereas in patients with wide extent of CAFG, the size of the areae gastricae decreased and the width of the intervening part of areae gastricae increased (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Most areae gastricae showed a foveola\u2010type micro\u2010mucosal structure (82.7%), while intervening part of areae gastricae had a groove\u2010type structure (98.0%, <jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001). Groove\u2010type mucosa had a higher grade of atrophy (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) and intestinal metaplasia (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001) compared with foveola type.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> As extent of CAFG widened, multifocal groove\u2010type mucosa that had high\u2010grade atrophy and intestinal metaplasia developed among areae gastricae and increased along the intervening part of areae gastricae. Our observations facilitate our understanding of the development and progression of CAFG.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2012.00938.x","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T11:49:25Z","timestamp":1332244165000},"page":"224-231","source":"Crossref","is-referenced-by-count":41,"title":["Comprehensive Investigation of Areae Gastricae Pattern in Gastric Corpus using Magnifying Narrow Band Imaging Endoscopy in Patients with Chronic Atrophic Fundic 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