{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:33:43Z","timestamp":1771061623809,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> (<jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>) infection is high, but the incidence of gastric cancer is low in natives of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladesh. The gastric mucosa was observed in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshi patients to investigate the differences between <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshis and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study involved 418 <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshi and 2356 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients with abdominal complaints who underwent endoscopy examinations and had no history of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication. The prevalence of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection and the gastric mucosa in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010positive patients were compared between age\u2010, gender\u2010, and endoscopic diagnosis\u2010matched <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshi and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection was higher in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshi than in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese subjects (60.2 and 45.1%, respectively). All the scores for chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia were significantly lower in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori\u2010<\/jats:italic>positive <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshis than in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori\u2010<\/jats:italic>positive <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese. The ratio of the corpus gastritis score (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) to the antrum gastritis score (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">C\/A<\/jats:styled-content> ratio) was &lt;1 (antrum\u2010predominant gastritis) in all age groups of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshi subjects, whereas the <jats:styled-content style=\"fixed-case\">C\/A<\/jats:styled-content> ratio changed from &lt;1 to more than 1 (corpus\u2010predominant gastritis) with aging in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The scores for glandular atrophy and intestinal metaplasia in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori\u2010<\/jats:italic>positive <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshis were significantly lower than those in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese. All age groups of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshis had antrum\u2010predominant gastritis, whereas corpus\u2010predominant gastritis was more common than antrum\u2010predominant gastritis in older <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese age groups. These results may explain the low incidence of gastric cancer in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>angladeshis and the high incidence in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1523-5378.2012.00967.x","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T07:27:03Z","timestamp":1341214023000},"page":"396-401","source":"Crossref","is-referenced-by-count":25,"title":["Observation of Gastric Mucosa in <scp>B<\/scp>angladesh, the Country with the Lowest Incidence of Gastric Cancer, and <scp>J<\/scp>apan, the Country with the Highest Incidence"],"prefix":"10.1111","volume":"17","author":[{"given":"Takeshi","family":"Matsuhisa","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Endoscopy Tama\u2010Nagayama University Hospital of Nippon Medical School 1\u20107\u20101 Nagayama Tama\u2010city Tokyo 206\u20108512 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafeza","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dhaka Medical College Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_5_4_1","unstructured":"World Health Organization.International Agency for Research on Cancer.http:\/\/globocan.iarc.fr\/"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05663.x"},{"key":"e_1_2_5_6_1","first-page":"47","article-title":"Genetic differences in interleukin\u20101 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H.\u00a0pylori infection and gastric cancer incidence","volume":"22","author":"Matsukura N","year":"2003","journal-title":"J Exp Clin Cancer Res"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2009.00368.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00121.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1329-y"},{"key":"e_1_2_5_10_1","first-page":"295","article-title":"Helicobacter pylori infection, glandular atrophy, intestinal metaplasia and topography of chronic active gastritis in the Nepalese and Japanese population: the age, gender and endoscopic diagnosis matched study","volume":"5","author":"Matsuhisa T","year":"2007","journal-title":"Kathmandu Univ Med J"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1951-6"},{"key":"e_1_2_5_12_1","unstructured":"AftabH MatsuhisaT AhmedF AhmedMM HasanM KhanAKA.Topography of chronic active gastritis among Helicobacter pylori positive patients in Bangladesh (abstract). 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