{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:41Z","timestamp":1791198521855,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T00:00:00Z","timestamp":1341964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Motility mediated by the flagella of <jats:italic>Helicobacter pylori<\/jats:italic> is important for the cells to move toward the gastric mucus in niches adjacent to the epithelium; then, <jats:italic>H.\u00a0pylori<\/jats:italic> uses the adhesin SabA to interact with sialyl\u2010Le<jats:sup>x<\/jats:sup> on inflammatory host cells for persistent infection. Here, we reveal the clinical association of bacterial motility, SabA expression, and pathological outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010six clinical isolates were screened for bacterial motility, and the expression of SabA of each isolate was confirmed by Western blotting. <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010infected patients were assessed for their bacterial density, sialyl\u2010Le<jats:sup>x<\/jats:sup> expression, inflammatory scores, and clinical diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean diameter in the motility assay was 17\u00a0mm, and eight (8.3%) of the strains had impaired motility, with a diameter &lt;5\u00a0mm. <jats:italic>H.\u00a0pylori<\/jats:italic> density in cardia, the acute inflammatory score in the body locus, and the prevalence rate of gastric atrophy were increased in patients infected with higher\u2010motility strains (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.023, &lt;.001, or &lt;.001, respectively). The total inflammatory scores (both acute and chronic) and bacterial density dramatically increased in patients expressing the sialyl\u2010Le<jats:sup>x<\/jats:sup> antigen and infected with higher\u2010motility, SabA\u2010positive <jats:italic>H.\u00a0pylori<\/jats:italic> (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.016, .01, or .005, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that the higher motility of <jats:italic>H.\u00a0pylori<\/jats:italic> enhances pathological outcomes, and the SabA\u2013sialyl\u2010Le<jats:sup>x<\/jats:sup> interaction has a synergistic effect on virulence of the higher\u2010motility strains.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1523-5378.2012.00974.x","type":"journal-article","created":{"date-parts":[[2012,7,11]],"date-time":"2012-07-11T06:35:08Z","timestamp":1341988508000},"page":"411-416","source":"Crossref","is-referenced-by-count":34,"title":["Higher Motility Enhances Bacterial Density and Inflammatory Response in Dyspeptic Patients Infected with <i>Helicobacter pylori<\/i>"],"prefix":"10.1111","volume":"17","author":[{"given":"Cheng\u2010Yen","family":"Kao","sequence":"first","affiliation":[{"name":"Institute of Basic Medical Sciences, College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor\u2010Shyang","family":"Sheu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shew\u2010Meei","family":"Sheu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Bai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology Ton\u2010Yen General Hospital  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Lun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"},{"name":"Department of Clinical Medicine College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Chi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn\u2010Jong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences, College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"},{"name":"Center of Infectious Disease and Signaling Research College of Medicine, National Cheng\u2010Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,11]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"33","article-title":"The prevalence of Helicobacter pylori infection in different countries","volume":"9","author":"Pounder RE","year":"1995","journal-title":"Aliment Pharmacol 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