{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:56:11Z","timestamp":1696308971488},"reference-count":21,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T00:00:00Z","timestamp":1347235200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Abstract<\/jats:title>The incidence of peptic ulcer disease has declined over the last few decades, particularly in Western populations, most likely as a result of the decrease in H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection and the widespread use of proton\u2010pump inhibitors (PPI<\/jats:styled-content>) in patients with dyspepsia. The hospital admission rate for uncomplicated duodenal and gastric ulcers has significantly decreased worldwide. In contrast, admissions for complicated ulcer disease, such as bleeding peptic ulcers and perforation, remained relatively stable. Prophylactic H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> eradication was found to be associated with a reduced risk of both gastric and duodenal ulcers and their complications, including bleeding in chronic users of nonsteroidal anti\u2010inflammatory drugs. The recent H<\/jats:styled-content>elicobacter<\/jats:italic> E<\/jats:styled-content>radication R<\/jats:styled-content>elief of D<\/jats:styled-content>yspeptic S<\/jats:styled-content>ymptoms trial presented important data relating to symptoms and quality of life of H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010positive patients with functional dyspepsia (FD<\/jats:styled-content>) and also demonstrated significant benefits from eradication compared with the control group. The new A<\/jats:styled-content>sian consensus report on FD<\/jats:styled-content> recommended that dyspepsia accompanied by H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection should be considered a separate disease entity from FD<\/jats:styled-content> and that H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> infection should be eradicated before diagnosing FD<\/jats:styled-content>. The association of H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> with gastroesophageal reflux disease (GERD<\/jats:styled-content>) is still controversial. Treatment for H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> does not seem to increase GERD<\/jats:styled-content> symptoms or reflux esophagitis. However, documented eradication of H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> appears to significantly improve GERD<\/jats:styled-content> symptoms. Additional long\u2010term intervention studies are needed to provide more information on which to base clinical decisions.<\/jats:p>","DOI":"10.1111\/j.1523-5378.2012.00978.x","type":"journal-article","created":{"date-parts":[[2012,9,10]],"date-time":"2012-09-10T07:01:36Z","timestamp":1347260496000},"page":"22-25","source":"Crossref","is-referenced-by-count":5,"title":["Helicobacter pylori<\/i> and Nonmalignant Diseases"],"prefix":"10.1111","volume":"17","author":[{"given":"Haim","family":"Shmuely","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Rabin Medical Center, Beilinson Hospital Petach Tiqva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslava","family":"Katicic","sequence":"additional","affiliation":[{"name":"University Hospital Merkur Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajana","family":"Filipec 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