{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:40:45Z","timestamp":1789422045946,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helicobacter"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has previously been reported that weak serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> but elevated <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibody responses against <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> may be associated with risk of gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) development. To search for potential immunologic markers for <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, we analyzed antibody responses against <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> in risk groups of cancer development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Sera and stomach biopsies collected from <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> patients as well as from patients with gastric ulcer (<jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content>), atrophic gastritis, intestinal metaplasia (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) and duodenal ulcer and from <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected control subjects without atrophy or <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>, and in addition from <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010negative subjects were analyzed for <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibodies against three different <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> antigen preparations, that is, membrane protein (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>), urease, and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ag<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed an increased serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> titer ratio against <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> anti\u2010<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GU<\/jats:styled-content> patients, and against <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ag<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>p\u2010infected <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> patients and risk groups. Female patients with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> had a higher serum anti\u2010<jats:styled-content style=\"fixed-case\">MP I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> titer ratio and a higher proportion of poorly differentiated cancer compared with male patients. As earlier observed, the non\u2010tumorous mucosa of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> patients contained considerably lower levels of total <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> compared with <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected controls. Similarly, we observed decreased specific mucosal anti\u2010<jats:styled-content style=\"fixed-case\">MP I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> response in patients with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed several differences in local and systemic immunologic responses against <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> in <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> patients and putative <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> risk group patients compared with <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>\u2010infected controls. These findings may be of importance in efforts to identify risk groups of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> or early stages of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1523-5378.2012.00991.x","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T10:27:25Z","timestamp":1348223245000},"page":"73-82","source":"Crossref","is-referenced-by-count":12,"title":["Immune Responses Against <i>Helicobacter pylori<\/i> in Gastric Cancer Patients and in Risk Groups for Gastric Cancer"],"prefix":"10.1111","volume":"18","author":[{"given":"Jenni","family":"Adamsson","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel B.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of 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