{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:52:34Z","timestamp":1772725954473,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T00:00:00Z","timestamp":1180051200000},"content-version":"vor","delay-in-days":1088,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p> <jats:italic>Numerous clinical studies have established that angiotensin II receptor blockers are effective as anti\u2010hypertensive therapy and are well tolerated. Studies demonstrate that adding an angiotensin II receptor blocker to existing antihypertensive regimens reduces cardiovascular and renal risk, which may, in part, be a result of blocking the effects of angiotensin II. Though the antihypertensive dose response of these agents is well documented, the dose response for optimal target organ protection has not yet been clarified. A review of recent studies of angiotensin II receptor blockers in hypertension, acute myocardial infarction, heart failure, and nephropathy provide some data on specific drugs, doses, and risk reduction. Taken as a whole, these studies suggest the highest doses tested, which are at the upper limit of the antihypertensive range, provide greater risk reduction than lower doses. What is unknown is whether even higher doses or full\u2010dose angiotensin II receptor blockers plus full\u2010dose angiotensin\u2010converting enzyme inhibitors might provide even greater risk reduction. Data from ongoing trials will provide additional insight.<\/jats:italic> <\/jats:p>","DOI":"10.1111\/j.1524-6175.2006.03473.x","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T16:02:04Z","timestamp":1180108924000},"page":"315-325","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin II Receptor Blockers: The Importance of Dose in Cardiovascular and Renal Risk Reduction"],"prefix":"10.1111","volume":"6","author":[{"given":"Matthew R.","family":"Weir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,25]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"589","article-title":"Angiotensin\u2010II receptor antagonists: a new class of antihypertensive agents","volume":"53","author":"Weir MR","year":"1996","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.6.1345"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.13.1905"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)01304-2"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1993.tb01939.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200007000-00012"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00103-X"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.5.1112"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.27.3.523"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08090-X"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200209000-00035"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200305000-00011"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/080370598437394"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/08037050152112069"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.22.2202"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00849-3"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00102-A"},{"key":"e_1_2_8_20_2","first-page":"7","article-title":"ACE inhibitor treatment after myocardial infarction","author":"Maggioni A","year":"1999","journal-title":"Eur Heart J"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01500-9"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09895-1"},{"key":"e_1_2_8_23_2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1056\/NEJMoa032292","article-title":"Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both","volume":"349","author":"Pfeffer MA","year":"2003","journal-title":"N Engl J Med"},{"key":"e_1_2_8_24_2","first-page":"821","article-title":"Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure","volume":"342","author":"The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators","year":"1993","journal-title":"Lancet"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209033271001"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512213332503"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420066040"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198706043162301"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001439"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01187-2"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02213-3"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010713"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02304-5"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9164(99)90013-1"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14283-3"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14282-1"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14285-7"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00230-3"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1520-765X(03)90045-9"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.4.421"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.8.1093"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0600031131.x"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-4-200308190-00006"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/14703203010020013401"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000054495.96193.BF"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00536.x"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12229-5"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011303"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011161"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011489"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1524-6175.2006.03473.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1524-6175.2006.03473.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1524-6175.2006.03473.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1524-6175.2006.03473.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:50:36Z","timestamp":1694433036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1524-6175.2006.03473.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1524-6175.2006.03473.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1524-6175.2006.03473.x","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}