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There is an ongoing debate regarding the proper treatment strategy for PTH suppression in this population. While some practitioners believe that calcitriol analogues should be the primary therapy in this setting, others contend that calcimimetics offer unique treatment benefits. Recent advancements in the understanding of the pathophysiology of secondary hyperparathyroidism and the secondary effects of these agents may help clarify this debate. Here, we review the classical actions of calcitriol analogues and calcimimetics on mineral metabolism. We also examine the potential nonclassical effects of these therapies on the renin\u2013angiotensin\u2013aldosterone system, proteinuria, vascular calcification, fibroblast growth factor\u201023, inflammation, and overall survival.<\/jats:p>","DOI":"10.1111\/j.1525-139x.2011.00935.x","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T10:07:15Z","timestamp":1308564435000},"page":"298-306","source":"Crossref","is-referenced-by-count":12,"title":["Does it Matter How Parathyroid Hormone Levels are Suppressed in Secondary Hyperparathyroidism?"],"prefix":"10.1111","volume":"24","author":[{"given":"Jason R.","family":"Stubbs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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