{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:36:15Z","timestamp":1779255375257,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T00:00:00Z","timestamp":1144108800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A 17\u2010year\u2010old boy had a 3\u2010year history of diabetes mellitus, malabsorption syndrome, and skin changes consisting of induration, hyperpigmentation, and hypertrichosis on the anterior aspect of both thighs, lower abdomen, and scrotum. Physical examination found hypogonadism, hepatomegaly, gynecomastia, growth retardation, and ankle edema. There was no neuropathy or plasma cell dyscrasia. However, the characteristic skin changes and the combination of symptoms suggest polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome. This is a rare multisystemic disorder of obscure pathogenesis and no conspicuous heredity. Overproduction of vascular endothelial growth factor is thought to cause microangiopathy, neovascularization, and accelerated vasopermeability causing the multiorgan deterioration. Cyclophosphamid cytostatic therapy seems beneficial.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2006.00201.x","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T16:02:54Z","timestamp":1144166574000},"page":"145-148","source":"Crossref","is-referenced-by-count":35,"title":["POEMS in Childhood"],"prefix":"10.1111","volume":"23","author":[{"given":"Sonya","family":"Marina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Broshtilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,4]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"2444","article-title":"Solitary plasmocytoma with polyneuritis and endocrine disturbance","volume":"26","author":"Shimpo S","year":"1968","journal-title":"Nippon Rinsho"},{"key":"e_1_2_4_3_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1001\/archderm.1987.01660250091026","article-title":"The skin changes in the Crow\u2013Fukase (POEMS) syndrome. 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