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We report a young girl with lamellar ichthyosis and symptoms of poisoning, with clinical signs of irritability, agitation, myoclonia, and difficulty in walking, accompanied by lactic acidosis as a result of the more frequent than recommended application of emollients containing lactic acid. The clinical symptoms resolved upon discontinuation of the topical treatment. Among the possible causes of metabolic acidosis, health care providers should be aware of the possibility of percutaneous poisoning.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2006.00236.x","type":"journal-article","created":{"date-parts":[[2006,6,12]],"date-time":"2006-06-12T15:28:57Z","timestamp":1150126137000},"page":"282-285","source":"Crossref","is-referenced-by-count":29,"title":["Acute Percutaneous Lactic Acid Poisoning in a Child"],"prefix":"10.1111","volume":"23","author":[{"given":"Manuela Esteban","family":"Ram\u00edrez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael Fasheh","family":"Youseef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser Garrido","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda Quintill\u00e1","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonia","family":"Gonz\u00e1lez\u2010Ense\u00f1at","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier Sanmart\u00ed","family":"Vilaplana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles Luaces","family":"Cubells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02761129"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-200106000-00015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00063110-200203000-00004"},{"key":"e_1_2_6_5_2","first-page":"23","article-title":"Emergency department visits for poisoning: epidemiological changes in the last 10 years","volume":"56","author":"Mintegui S","year":"2002","journal-title":"An Esp Pediatr"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.S3.1114"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(03)00046-4"},{"key":"e_1_2_6_8_2","first-page":"1339","volume-title":"Textbook of dermatology","author":"Griffiths WAD","year":"1992"},{"key":"e_1_2_6_9_2","first-page":"413","volume-title":"Pediatric dermatology","author":"Williams ML","year":"1995"},{"key":"e_1_2_6_10_2","first-page":"58","article-title":"Lamellar ichthyosis: a case report","volume":"44","author":"Ozyurek H","year":"2002","journal-title":"Turk J Pediatr"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.110308.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200353"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.23.2867"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13693"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(03)00051-8"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405010-00004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03200.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb08902.x"},{"key":"e_1_2_6_19_2","first-page":"149","volume-title":"Diagn\u00f3stico y tratamiento de las enfermedades cong\u00e9nitas del metabolismo.","author":"Del Toro M","year":"2001"},{"key":"e_1_2_6_20_2","first-page":"571","article-title":"Acute salicylate intoxication after transcutaneous absorption","volume":"65","author":"Pertoldi F","year":"1999","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200209060-00025"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1001\/jama.1985.03350350100031","article-title":"Hyperosmolality induced by propylene glycol. 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