{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:46:02Z","timestamp":1780047962902,"version":"3.53.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Phrynoderma is a rare form of follicular hyperkeratosis associated with deficiencies in vitamins A or C or essential fatty acids. We report a 6\u2010year\u2010old boy with an unusual presentation of phrynoderma, characterized by multiple minute digitate hyperkeratoses associated with hair casts and related to a severe deficiency in vitamins A and C complicating a chronic intestinal giardiasis. The lesions responded well to oral vitamins A and C combined with albendazole treatment. Vitamin A deficiency\u2010related phrynoderma is rare in western countries and is usually caused by digestive malabsorption resulting from large intestine resection or pancreatic failure. To our knowledge, this is the first reported instance of phrynoderma related to a chronic intestinal parasitic infection by <jats:italic>Giardia intestinalis<\/jats:italic> with intestinal malabsorption as a likely consequence.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2006.00261.x","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T20:29:00Z","timestamp":1155068940000},"page":"346-349","source":"Crossref","is-referenced-by-count":47,"title":["Vitamin A Deficiency Phrynoderma Associated with Chronic Giardiasis"],"prefix":"10.1111","volume":"23","author":[{"given":"C\u00e9line","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dereure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Blati\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Bessis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"681","article-title":"Phrynoderma: a condition due to vitamin deficiency","volume":"68","author":"Nicholls L","year":"1933","journal-title":"Indian Med Gaz"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1936.01470110045005"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70144-4"},{"key":"e_1_2_4_5_2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/archderm.1986.01660200099025","article-title":"Hair casts","volume":"122","author":"Keipert JA","year":"1986","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_6_2","first-page":"460","article-title":"Multiple minute digitate hyperkeratoses","volume":"9","author":"Ramselaar C","year":"1999","journal-title":"Eur J Dermatol"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70375-0"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650430105019"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/014107688808100319","article-title":"Phrynoderma and perforating folliculitis due to vitamin A deficiency in a diabetic","volume":"81","author":"Neill SM","year":"1988","journal-title":"J R Soc Med"},{"key":"e_1_2_4_10_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/archderm.1979.04010010045013","article-title":"Vitamin A deficiency following small\u2010bowel bypass surgery for obesity","volume":"115","author":"Weschler HL","year":"1979","journal-title":"Arch Dermatol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70260-0"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02414.x"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2006.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2006.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:30:37Z","timestamp":1697113837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2006.00261.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1525-1470.2006.00261.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2006.00261.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}