{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:39:03Z","timestamp":1787510343327,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T00:00:00Z","timestamp":1300147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract:\u2003<\/jats:bold>\n                    Previously reported cases of acute generalized exanthematous pustulosis secondary to brown recluse spider bite have been questioned due to lack of identification of the spider or because of the concomitant administration of antibiotics. We report a 9\u2010year\u2010old boy who arrived at the emergency department with a confirmed\n                    <jats:italic>Loxosceles reclusa<\/jats:italic>\n                    bite to the neck. On the third day of hospitalization, he developed hundreds of monomorphous, sterile pustules, initially in intertriginous areas. The eruption disseminated and was followed by pinpoint desquamation typical for acute generalized exanthematous pustulosis. During this he also developed late onset Coombs\u2010positive hemolytic anemia and systemic loxoscelism. Sphingomyelinase in\n                    <jats:italic>Loxosceles<\/jats:italic>\n                    venom induces the production of interleukin\u20108 and granulocyte\u2010macrophage colony\u2010stimulating factor, cytokines involved in the pathogenesis of acute generalized exanthematous pustulosis, providing a mechanism by which\n                    <jats:italic>Loxosceles reclusa<\/jats:italic>\n                    bite may trigger acute generalized exanthematous pustulosis. We suggest that this case adds\n                    <jats:italic>Loxosceles<\/jats:italic>\n                    envenomation to the spectrum of agents that can trigger acute generalized exanthematous pustulosis.\n                  <\/jats:p>","DOI":"10.1111\/j.1525-1470.2010.01302.x","type":"journal-article","created":{"date-parts":[[2011,3,15]],"date-time":"2011-03-15T22:16:16Z","timestamp":1300227376000},"page":"685-688","source":"Crossref","is-referenced-by-count":36,"title":["Acute Generalized Exanthematous Pustulosis and Coombs\u2010Positive Hemolytic Anemia in a Child Following\n                    <i>Loxosceles reclusa<\/i>\n                    Envenomation"],"prefix":"10.1111","volume":"28","author":[{"given":"Leanna","family":"Lane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly H.","family":"McCoppin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,15]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080069004"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.11.006"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.010"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.08-CR-0035"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08156.x"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1172"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00346.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041184"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12118"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2004.08.028"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.08.011"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2007.12.003"},{"key":"e_1_2_4_14_2","first-page":"341","article-title":"Coombs\u2010positive hemolytic anemia secondary to brown recluse spider bite: a review of the literature and discussion of treatment","volume":"74","author":"Lane DLR","year":"2004","journal-title":"Cutis"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2010.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2010.01302.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/j.1525-1470.2010.01302.x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2010.01302.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T02:35:07Z","timestamp":1693276507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2010.01302.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,15]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1111\/j.1525-1470.2010.01302.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2010.01302.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,15]]}}}