{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:39:12Z","timestamp":1791599952723,"version":"4.3.4"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T00:00:00Z","timestamp":1304985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Pachyonychia congenita is a rare genodermatosis that can affect the larynx. Laryngeal obstruction is very unusual with only a few cases reported. A 2\u2010year\u2010old girl presented with typical clinical features of pachyonychia congenita shortly after birth. At age 9\u2003months, following an upper respiratory infection, she developed stridor and hoarseness and was found to have severe laryngeal obstruction, which was felt to be secondary to pachyonychia congenita based on direct laryngoscopy and laryngeal biopsy. Leukokeratosis of her larynx was treated with CO<jats:sub>2<\/jats:sub> laser on three occasions, with improvement in her respiratory distress after each treatment. This report is the first case of pachyonychia congenita with laryngeal obstruction in which the gene mutation has been established (a deletional mutation in K6a), confirming that laryngeal obstruction can occur in PC\u20101.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2011.01232.x","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T11:31:17Z","timestamp":1305027077000},"page":"429-432","source":"Crossref","is-referenced-by-count":11,"title":["Pachyonychia Congenita with Laryngeal Obstruction"],"prefix":"10.1111","volume":"28","author":[{"given":"Richard M.","family":"Haber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,10]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"JadassohnJ LewandowskiF.Pachyonychia congenita: keratosis disseminata circumscripta (folliculosis). Tylomata. Leukokeratosis linguae Berlin Urban and Schwarzenberg 29\u201331 1906."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(05)80008-2"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680040109013"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10202.x"},{"key":"e_1_2_6_6_2","first-page":"174","article-title":"Uber pachyonychia congenita (Typus Riehl)","volume":"48","author":"Kumer L","year":"1935","journal-title":"Wien Klin Wochenschr"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10204.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780090075011"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140105"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(87)90097-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12527.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)01074-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1643"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2011.01232.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2011.01232.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:46:32Z","timestamp":1698756392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2011.01232.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,10]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1111\/j.1525-1470.2011.01232.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2011.01232.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,10]]}}}