{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:29:56Z","timestamp":1761128996838},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T00:00:00Z","timestamp":1337558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We present the case of an 8\u2010year\u2010old girl who presented with distal extremity necrosis of the hands, feet, nose, and ears as an acute manifestation of cutaneous polyarteritis nodosa (CPAN). She was emergently managed with intravenous steroids, nifedipine, sildenafil, pentoxifylline, nitroglycerin paste, aspirin, low\u2010molecular\u2010weight heparin, and intravenous gamma globulin. The necrosis was controlled, and reperfusion was attained to salvage the extremities. It is important for clinicians to be aware that acute distal extremity necrosis can be a manifestation of CPAN in children. Etiology is often not clear on presentation, but once infection is excluded, acute management with systemic steroids and systemic vasodilators is indicated regardless of the cause. Iloprost and bosentan may represent options for adjunctive vasodilators. More studies are needed to create guidelines for the acute and long\u2010term management of these children. Close follow\u2010up of children with CPAN, especially with a history of vaso\u2010occlusive symptoms, is important to allow prompt intervention in the event of distal extremity infarction.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2011.01515.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T12:54:00Z","timestamp":1337604840000},"page":"473-478","source":"Crossref","is-referenced-by-count":17,"title":["Distal Extremity Necrosis as a Manifestation of Cutaneous Polyarteritis Nodosa: Case Report and Review of the Acute Management of a Pediatric Patient"],"prefix":"10.1111","volume":"29","author":[{"given":"Victoria L.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Guirola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristy","family":"Flemming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunjan M.","family":"Modi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Rosales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marietta M.","family":"DeGuzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.065"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1998.tb01291.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050300"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H637"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.1.48"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01453.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.2.134"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000066789.79129.C2"},{"key":"e_1_2_5_10_2","first-page":"512","volume-title":"Textbook of pediatric rheumatology","author":"Cassidy JT","year":"2006"},{"key":"e_1_2_5_11_2","first-page":"341","article-title":"Use of drug therapy to manage acute cutaneous necrosis of the skin","volume":"9","author":"Wallace JS","year":"2010","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181c76bab"},{"key":"e_1_2_5_13_2","first-page":"360","article-title":"Therapeutic uses of calcium channel\u2010blocking drugs in the young","volume":"140","author":"Cho C","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.64"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.034488"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.5070\/D36270C6VM"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg480"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.2165\/10489160-000000000-00000"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199504000-00008"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2011.01515.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2011.01515.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T06:17:47Z","timestamp":1698646667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2011.01515.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,21]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1525-1470.2011.01515.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2011.01515.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,21]]}}}