{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:51:07Z","timestamp":1784749867303,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T00:00:00Z","timestamp":1348531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Vascular lesions such as hemangiomas and lymphangiomas can cause significant mortality and morbidity, as well as amblyopia when located in the orbit. Oral propranolol can regress infantile hemangioma during infancy and up to 23\u2003months of age, but its effect on lymphangioma has not been demonstrated. We present two cases of lymphatic malformations treated with oral propranolol. Patient 1 is a 2\u2010year\u2010old boy with macrocystic bilateral cervical lymphangioma extending to the pharynx and larynx and microcystic lymphangioma of the tongue. The patient was started on propranolol 2\u2003mg\/kg\/day starting at 17\u2003months of age, and after 3\u2003months only a very slight decrease in tongue volume was noted. Patient 2 is a 3.5\u2010year\u2010old boy with magnetic resonance imaging evidence of right facial complex lymphangioma with venous malformation. The patient was placed on oral propranolol 2\u2003mg\/kg\/day. After 3\u2003months of treatment, no change in the lesion was noted except for a transient decrease in the size of the conjunctival telangiectasia. Propranolol 2\u2003mg\/kg\/day was not effective in treating lymphatic malformations in two children, both older than 17\u2003months at the time of treatment.<\/jats:p>","DOI":"10.1111\/j.1525-1470.2012.01864.x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T19:49:29Z","timestamp":1348602569000},"page":"383-385","source":"Crossref","is-referenced-by-count":38,"title":["Lack of Effect of Propranolol in the Treatment of Lymphangioma in Two Children"],"prefix":"10.1111","volume":"30","author":[{"given":"Annabel","family":"Maruani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Lorette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soizick","family":"Pondaven\u2010Letourmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Herbreteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Eisenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,25]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.02.025"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20155"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2009.04.013"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(99)90168-9"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.03.013"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02344.x"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0525-5"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991201)86:11<2406::AID-CNCR31>3.0.CO;2-E"},{"key":"e_1_2_4_11_2","first-page":"513","article-title":"Vascular endothelial growth factor: basic science and clinical progress","volume":"24","author":"Ferrara N","year":"2004","journal-title":"Endocr Rev"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971201)67:3<353::AID-JCB7>3.0.CO;2-V"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09848.x"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2010.08.002"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1013217"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.043"}],"container-title":["Pediatric Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1525-1470.2012.01864.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1525-1470.2012.01864.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T22:00:00Z","timestamp":1698703200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1525-1470.2012.01864.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,25]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/j.1525-1470.2012.01864.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1525-1470.2012.01864.x","archive":["Portico"],"relation":{},"ISSN":["0736-8046","1525-1470"],"issn-type":[{"value":"0736-8046","type":"print"},{"value":"1525-1470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,25]]}}}